ArticleFrontiers in veterinary science2025
Emergence and evolution of epizootic hemorrhagic disease virus in the Mediterranean region: spatio-temporal dynamics and epidemiological insights.
Article in Frontiers in veterinary science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- Isolating the first strain of epizootic hemorrhagic disease virus serotype 2 (EHDV-2) in mainland China.Veterinary research communications · 2026Article
- Genomic Epidemiology and National Seroprevalence Reveal the Widespread Distribution of Palyam Viruses in China.Viruses · 2026Article
- Epizootic Haemorrhagic Disease Virus (EHDV) Infection in Red Deer (Animals : an open access journal from MDPI · 2026Article
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9 authors.
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Abstract
Background: Epizootic Hemorrhagic Disease Virus (EHDV) is an arbovirus, transmitted to wild and domestic ruminants through Culicoides biting midges. Since 2006, high morbidity and mortality cases of EHDV have been reported among cattle and deer populations in several Mediterranean countries. The temporal and geographic origins of these incursions remained unclear. In this study, we aimed to investigate the evolutionary history of EHDV in the Mediterranean region and highlight the epidemiological features of viruses in relationship with genetic diversity and viral ecology. Methods: We extracted from GenBank the EHDV VP2 and VP5 segments isolated in the mediterranean region during the period 2006 to 2023 and blasted them to obtain a final dataset of 68 and 91 nucleotide sequences. Using these datasets, we conducted a Bayesian phylodynamic analysis, which inferred discrete models of "geographic origin," "Serotype" and "Host" by employing the BEAST package. Results: RSPP and TMRCA analyses showed that the Mediterranean EHDV has as ancestral root the North America strains that circulated in the 17 Conclusion: The virus transmission was intense between North African and European countries of the Mediterranean region. EHDV spread in this region seems to be influenced mainly by vector/host distribution and abundance, ruminants' trade and prevailing winds.
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