ArticleTranslational pediatrics2025
Comparison of cycloplegic effects of atropine and tropicamide in children with refractive error.
Article in Translational pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- 3D choroidal vascularity index in hyperopic amblyopic eyes of preschool children: a case-control study using SS-OCTA.International journal of ophthalmology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Refractive error is the primary cause of vision impairment in children and requires accurate cycloplegic refraction for proper diagnosis and treatment. Various cycloplegic agents are used clinically, but their comparative efficacy remains controversial, particularly across different pediatric age groups and refractive error types. The purpose of this study was to observe the cycloplegic effects of tropicamide and atropine in children of different ages and different refractive errors, and to screen out more suitable drugs for cycloplegia in children with different refractive errors. Methods: This study is a prospective cohort study. In this study, 110 children with refractive error were first dilated with 4 g/L of tropicamide eye drops; after the pupils recovered, they were dilated with 8 g/L of atropine eye ointment, and the results of the two pupil dilation methods were compared. Results: In hyperopic eyes, the cycloplegic refraction obtained using the two methods was the same spherical correction in 8.45%; cylindrical correction differed by >0.25 D in 91.54%, 14.28% were the same, and 85.71% had a difference of ≥0.25 D. Compared with refraction using tropicamide, atropine refraction had a significantly higher mydriatic effect on spherical and cylindrical lenses in all age groups, and the difference was statistically significant (P<0.001). In the myopia group, among the spherical lenses, 13.04% of the eyes were the same, and 86.9% of the eyes had differences; among the cylindrical lenses, 20% of the eyes were the same, and 80% of the eyes had differences. The cycloplegic effect of 4 g/L of tropicamide eye drops on spherical and cylindrical lenses was less than that of 8 g/L of atropine eye ointment. In the mixed astigmatism group, among spherical lenses, 14 eyes had differences, accounting for 100.0% of cases, with the maximum difference being 1.25 D; among cylindrical lenses, 5 eyes had the same results between the two pupil dilation methods, accounting for 35.7% of cases, and 64.3% had a difference of 0.25-0.5 D. Conclusions: In children under 12 years old with mixed astigmatism and hyperopia, cycloplegic refraction using atropine is preferred over tropicamide.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.