ArticleTranslational pediatrics2025
Case report: diagnostic challenges and long-term survival of a child with bronchial mucoepidermoid carcinoma.
Article in Translational pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Bronchial mucoepidermoid carcinoma (MEC) is a rare pediatric malignant neoplasm of difficult diagnosis. Case Description: We report on the case of a 15-year-old patient who presented with cough, fever, left chest pain, and difficulty breathing. A chest computed tomography (CT) scan revealed collapse of the left lung with a solid mass with poorly defined margins located close to the left lung hilum, and another smaller enhancing solid nodule located adjacent to the aortic arch. Biopsy of the lesion revealed a malignant epithelial neoplasm with clear cell morphology, overexpression of TFE3 by immunohistochemistry (IHC), but without TFE3 rearrangement by fluorescence in situ hybridization (FISH) analysis. Transcriptome [RNA sequencing (RNA-seq)] analysis of the specimen was positive for Conclusions: Clinical presentation of bronchial MEC is similar to that of other pulmonary neoplasms. In our challenging case, the identification of
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