ArticleTranslational pediatrics2025
Novel endoplasmic reticulum stress-related gene signature unveils CDKN3 as a prognosticator in neuroblastoma.
Article in Translational pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
- Comparative Functional Effects of Abemaciclib and Arcyriaflavin A inInternational journal of molecular sciences · 2026Article
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5 authors.
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Abstract
Background: Neuroblastoma (NB) is the most common extracranial solid tumor in children and a major cause of pediatric cancer mortality. This study aims to develop an endoplasmic reticulum (ER) stress-based risk model to evaluate patient prognosis, identify novel therapeutic targets, and predict immunotherapy responses. Methods: NB cases with transcriptome and clinical data were obtained from Gene Expression Omnibus (GEO) and ArrayExpress databases. ER stress-related genes were extracted from GeneCards. Differentially expressed genes (DEGs) were identified to construct an ER stress-related gene signature for prognosis prediction. The predictive ability was assessed using survival analysis, receiver operating characteristic (ROC) curves, and statistical tools. The relationship between the ER stress risk score and clinicopathological features, immune infiltration, and drug sensitivity was evaluated. A predictive nomogram was developed for prognostic accuracy. Immunohistochemistry (IHC) validated the hub gene using NB clinical specimens. Results: A five-gene signature ( Conclusions: This five-gene model linked to ER stress can independently forecast NB prognosis and correlates with immune and antitumor agent susceptibility, providing a basis for personalized treatment strategies.
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