ArticleTranslational pediatrics2025
Global, regional, and national burden of neonatal infectious diseases from 1990 to 2021.
Article in Translational pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- The Role of Neonatal Ward Environment as a Reservoir for the Dissemination of Multidrug-Resistant Klebsiella pneumoniae in Algeria.MicrobiologyOpen · 2026Article
- Incidence of Neonatal Meningitis and the Premature Mortality in Eastern Sub-saharan Africa, From 1990 to 2023: A Global Burden of Diseases Study.Sage open pediatricsArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Neonatal infectious diseases are very common during the neonatal period, and severe neonatal infections such as sepsis, meningitis, pneumonia can be life-threatening. Despite significant advances in neonatal medicine, neonatal sepsis is still the third leading cause of neonatal mortality and accounts for nearly half of all deaths in children under five globally. However, comprehensive data on the incidence, disability-adjusted life years (DALYs), and trends of these diseases remain scarce. This study leverages the Global Burden of Disease (GBD) database to evaluate the global, regional, and national burdens of neonatal infectious diseases. Methods: We extracted data from the GBD database, covering neonatal sepsis and other infectious diseases from 1990 to 2021, focusing on incidence and DALYs. We calculated the estimated annual percentage change (EAPC) to assess trends in incidence and DALYs and employed joinpoint regression to determine the annual percentage change (APC) and average APC (AAPC). The data were stratified by sex, age, socio-demographic index (SDI), region, and country. Results: From 1990 to 2021, a global decline in both the incidence and DALYs rates of neonatal infectious diseases was observed [AAPC -0.71 (incidence), -0.70 (DALYs)]. Males and 0-6 days neonates had higher risk in neonatal infectious diseases. The majority of the disease burden was concentrated in countries with lower SDI values, and Africa had higher disease burden with lower SDI values. Conclusions: The worldwide burden of neonatal infectious diseases has decreased over the past decades and is inversely related to SDI values. Continued efforts are needed to address these disparities and further reduce the impact of these diseases.
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