Evidence map›Paper›PMID 40800122›Full record

ArticleNeuro-oncology advances

Cerebrospinal fluid liquid biopsy guides differential diagnosis of relapsed medulloblastoma versus secondary glioma: A case report of a pediatric patient enrolled on a

Tom T Fischer, Kendra K Maass, Melanie Schoof, Pitithat Puranachot, Philipp Sievers, Sophia Montigel, Theresa Fluhr, Ahmed El Damaty, Angelika Seitz, Semi Harrabi and 9 more

Abstract read
In one paragraph

Article in Neuro-oncology advances. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Tom T FischerHeidelberg Biosciences International Graduate School (HBIGS), Faculty of Biosciences, Heidelberg University, Heidelberg, Germany.ORCID https://orcid.org/0000-0002-2138-9102
Kendra K MaassNational Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.ORCID https://orcid.org/0000-0001-9357-5038
Melanie SchoofResearch Institute Children's Cancer Center Hamburg, Hamburg, Germany.ORCID https://orcid.org/0000-0002-1373-8130
Pitithat PuranachotPrincess Srisavangavadhana Faculty of Medicine, Chulabhorn Royal Academy, Bangkok, Thailand.ORCID https://orcid.org/0000-0002-6786-9240
Philipp SieversClinical Cooperation Unit Neuropathology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID https://orcid.org/0000-0003-3237-6021
Sophia MontigelNational Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.ORCID https://orcid.org/0009-0006-9796-355X
Theresa FluhrDepartment of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, Heidelberg Faculty of Medicine, Heidelberg University, Heidelberg, Germany.ORCID https://orcid.org/0009-0002-4965-8260
Ahmed El DamatyDepartment of Neurosurgery, Heidelberg University Hospital, Heidelberg Faculty of Medicine, Heidelberg University, Heidelberg, Germany.ORCID https://orcid.org/0000-0003-0146-8943
Angelika SeitzDepartment of Neuroradiology, Heidelberg University Hospital, Heidelberg Faculty of Medicine, Heidelberg University, Heidelberg, Germany.
Semi HarrabiDepartment of Radiation Oncology, Heidelberg University Hospital, Heidelberg Faculty of Medicine, Heidelberg University, Heidelberg, Germany.ORCID https://orcid.org/0000-0003-1195-7150
Kathrin SchrammDivision of Pediatric Glioma Research, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany.
Dominik SturmDivision of Pediatric Glioma Research, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID https://orcid.org/0000-0003-0250-1696
David T W JonesDivision of Pediatric Glioma Research, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID https://orcid.org/0000-0002-2036-5141
Stefan M PfisterNational Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.ORCID https://orcid.org/0000-0002-5447-5322
Olaf WittClinical Cooperation Unit Pediatric Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID https://orcid.org/0000-0003-3918-9157
Cornelis M van TilburgClinical Cooperation Unit Pediatric Oncology, German Cancer Consortium (DKTK) and German Cancer Research Center (DKFZ), Heidelberg, Germany.ORCID https://orcid.org/0000-0001-5274-910X
Till MildeComprehensive Cancer Center Central Germany (CCCG), Jena, Germany.ORCID https://orcid.org/0000-0002-7267-1052
Ulrich SchüllerInstitute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.ORCID https://orcid.org/0000-0002-8731-1121
Kristian W PajtlerNational Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and Heidelberg University Hospital, Heidelberg, Germany.ORCID https://orcid.org/0000-0002-3562-6121

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Liquid biopsies have the potential to substantially transform clinical oncology, but their technical applicability and clinical utility in pediatric neuro-oncology remain to be explored. Here, we present a case of a medulloblastoma patient in which a cerebrospinal fluid liquid biopsy provided an accurate molecular tumor classification of a secondary glioma during follow-up. Using Nanopore sequencing and low-coverage whole genome sequencing pipelines optimized for cell-free DNA, the liquid biopsy revealed a

Indexed as

cell-free DNAcerebrospinal fluid liquid biopsymolecular biomarkerspediatric neuro-oncologysecondary glioma

Identifiers

PMID40800122
PMCPMC12342540

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.