Evidence map›Paper›PMID 40800061›Full record

ArticleCerebral circulation - cognition and behavior2025

Effect of carotid artery stenosis on cortical microinfarcts, white matter integrity, and brain volume: An interhemispheric comparison within the population-based Rotterdam Study.

Frank J Wolters, Meike W Vernooij, Gennady V Roshchupkin, M Arfan Ikram, Maryam Kavousi, Peter J Koudstaal, Aad van der Lugt, Daniel Bos

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Article in Cerebral circulation - cognition and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

8 authors.

Frank J WoltersDepartment of Epidemiology, Erasmus MC - University Medical Center Rotterdam, Rotterdam, the Netherlands.
Meike W VernooijDepartment of Epidemiology, Erasmus MC - University Medical Center Rotterdam, Rotterdam, the Netherlands.
Gennady V RoshchupkinDepartment of Radiology and Nuclear Medicine, Erasmus MC - University Medical Center Rotterdam, Rotterdam, the Netherlands.
M Arfan IkramDepartment of Epidemiology, Erasmus MC - University Medical Center Rotterdam, Rotterdam, the Netherlands.
Maryam KavousiDepartment of Epidemiology, Erasmus MC - University Medical Center Rotterdam, Rotterdam, the Netherlands.
Peter J KoudstaalDepartment of Neurology, Erasmus MC - University Medical Center Rotterdam, Rotterdam, the Netherlands.
Aad van der LugtDepartment of Radiology and Nuclear Medicine, Erasmus MC - University Medical Center Rotterdam, Rotterdam, the Netherlands.
Daniel BosDepartment of Epidemiology, Erasmus MC - University Medical Center Rotterdam, Rotterdam, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Carotid artery stenosis could contribute to gradual loss of brain function through chronic hypoxia and ischemia. Methods: We included consecutive participants of the population-based Rotterdam Study with unilateral ≥50 % stenosis at the carotid artery bifurcation on time-of-flight carotid MR angiography, and compared between hemispheres the presence of ischemic lesions, tissue volumes, and white matter integrity on structural brain MRI. Results: Among 50 participants (mean age 76 years, 50 % women), flow was lower in the affected carotid artery than on the unaffected side (160mL/min versus 202mL/min; flow reduction [95 %CI] per 1 % increase in stenosis: 1.7 mL/min [1.0-2.5]). Twelve individuals had radiographic evidence of cortical infarction, of whom 8 had cortical microinfarcts, all on the side of the stenosis ( Conclusions: Carotid artery stenosis is associated with downstream presence of cortical microinfarcts as well as lower parenchymal tissue volume.

Indexed as

Carotid artery stenosisCerebral blood flowCerebral small-vessel diseaseCortical microinfarctsNeurodegeneration

Identifiers

PMID40800061
PMCPMC12340556

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.