ArticleFrontiers in public health2025
Associations between the METS-IR index and cognitive function in community-dwelling Chinese middle-aged and older adult individuals: a cross-sectional study.
Article in Frontiers in public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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7 authors.
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Abstract
Objective: The relationship between insulin resistance and cognitive function has long been a subject of interest, but the association between the metabolic syndrome-insulin resistance (METS-IR) index and cognitive impairment remains unclear. Methods: We utilized data from the 2015 China Health and Retirement Longitudinal Study (CHARLS) national survey, which, after screening, included a final sample of 12,307 participants. Cognitive function was assessed through face-to-face interviews via the MMSE scale. Multivariate logistic regression was used to evaluate the correlation between the METS-IR index and cognitive impairment. Using regression analysis results from fully adjusted models, we subsequently explored the nonlinear relationship between the METS-IR index and cognitive impairment via smooth curve fitting with constrained cubic splines and sought potential inflection points. Additionally, we executed a battery of sensitivity and subgroup analyses to validate the robustness of our findings. Results: The study included 12,307 participants, of whom 49.02% were aged 45-60 years and 52.89% were female. The results revealed that for each unit increase in the METS-IR index, the risk of cognitive impairment increased by 1.4% ( Conclusion: This study highlighted the significant association between high METS-IR and the risk of cognitive impairment in Chinese middle-aged and older adult individuals. In addition, there was a specific nonlinear relationship between the METS-IR index and cognitive impairment (the inflection point was 38.1). Lowering the METS-IR index below 38.1 through lifestyle changes and diet control can significantly reduce the risk of cognitive impairment and may decrease the incidence of dementia.
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