ReviewMaterials today. Bio2025
Research progress on the advantages, mechanisms and design strategies of nanomaterials for immunomodulatory angiogenesis.
Review in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Advances in biomimetic mineralized biomaterials for bone tissue engineering.Regenerative biomaterials · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Owing to the difficulty in achieving effective and timely vascularization, repairing the structure and function of damaged tissues and organs remains a major challenge in clinical practice. The immune microenvironment is a key factor affecting angiogenesis; however, traditional strategies have failed to take full advantage of this property. Recent advances in nanomaterial design have shifted from "immune avoidance" to "immune interaction", representing a breakthrough in promoting angiogenesis. An increasing number of studies have reported that nanomaterials(NMs) can induce and regulate immune cells or immune metabolic reprogramming to promote angiogenesis, but few studies have investigated the specific mechanism by which NMs affect immune cells and how they are involved in different stages of angiogenesis. This article reviews the advantages of NMs and focuses on the specific mechanisms by which NMs regulate immune cells, including immune extracellular regulation (changes in the physical and chemical environment), the regulation of membrane receptors and membrane potential, and regulation within immune cells, such as the metabolic activity of immune cells. According to the application scenarios of tissue regeneration (bone, skin, nerve and cardiovascular tissue), the influencing factors and design smart nanomaterials through immune regulation are summarized, and the current challenges and development directions of NMs in clinical applications are proposed, particularly in precision medicine and clinical transformation. This review provides a theoretical basis for an in-depth understanding of NMs and immunomodulatory vascularization for tissue regeneration to optimize the design strategy, rational development and clinical application of NMs in the field of immunovascularization.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.