Evidence map›Paper›PMID 40799955›Full record

ArticleWorld journal of pediatric surgery2025

Brainstem microglial cell morphology in neonatal rats with necrotizing enterocolitis and the effects of prenatal heparin-binding epidermal growth factor-like growth factor.

Vonita Chawla, Yomara S Mendez, Lorraine C Siebold, Julia C Vickery, Marla A Sacks, Georgi D Mladenov, Andrei Radulescu, Christopher G Wilson

Abstract read
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In one paragraph

Article in World journal of pediatric surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Vonita ChawlaDepartment of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.ORCID https://orcid.org/0000-0003-4298-6421
Yomara S MendezThe David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA.
Lorraine C SieboldLoma Linda University School of Medicine, Loma Linda, California, USA.
Julia C VickeryDepartment of Pediatrics, Columbia University Irving Medical Center, New York, New York, USA.
Marla A SacksDepartment of General Surgery, SUNY Downstate Health Sciences University, New York, New York, USA.ORCID https://orcid.org/0000-0002-6917-8398
Georgi D MladenovDepartment of Pediatric Surgery, Loma Linda University, Loma Linda, California, USA.ORCID https://orcid.org/0000-0001-6047-2948
Andrei RadulescuDepartment of Pediatric Surgery, Loma Linda University, Loma Linda, California, USA.
Christopher G WilsonLawrence D Longo MD center for perinatal biology, Loma Linda University, Loma Linda, California, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

abstractBackground: Necrotizing enterocolitis (NEC) is associated with increased neurodevelopmental impairment. Gut-brain interactions through the brainstem may be central to NEC-related microglia-driven neuroinflammation. Heparin-binding epidermal growth factor-like growth factor (HB-EGF) has intestinal protective properties and is a potential therapy for NEC. The aim of this study is to test the hypothesis that HB-EGF in pregnant rats reduces both NEC incidence and proinflammatory changes in the brainstem microglia of newborn rats. Methods: We compared four experimental groups, HB-EGF Results: NEC incidence was lower in the HB-EGF Conclusions: Prenatal HB-EGF treatment reduces NEC incidence in neonatal rats. NEC-related proinflammatory changes are seen in microglial cells present in crucial centers controlling the gut-brain pathway. HB-EGF has a growth-promoting effect on healthy microglia in the offspring but does not avert microglial activation in the brainstem of newborn rats with NEC.

Indexed as

NeonatologyPediatrics

Identifiers

PMID40799955
PMCPMC12336531

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.