ArticleInfection and drug resistance2025
Ceftazidime-Induced Overexpression of MexJK-OprM Confers Resistance to Ceftolozane/Tazobactam in an Isolate of
Article in Infection and drug resistance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: The emergence of resistance to ceftolozane/tazobactam (CTLZ/TAZ) in Methods: A TAZ/CTLZ-resistant Results: Pa-R and Pa-S were genetically identical and lacked carbapenemase genes. No mutations or overexpression of Conclusion: This study demonstrated that overexpression of the MexJK-OprM efflux pump is a key mechanism underlying TAZ/CTLZ resistance. In addition, prior administration of CAZ contributed to the acquisition of resistance, highlighting the need to consider the risk of resistance acquisition when switching antibiotics. In such cases, the choice of carbapenems should be considered.
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