ArticleFrontiers in cellular and infection microbiology2025
The predictive value of SOFA and APSIII scores for 28-day mortality risk in SIMI: a cohort study based on the MIMIC-IV database.
Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed.
- The associations among iron metabolism markers, iron supplementation regimen, and sepsis-induced myocardial injury: a retrospective study.Frontiers in nutrition · 2026Article
- Early metoprolol use in ICU patients with congestive heart failure is associated with increased 30-day mortality: a causal machine learning study.Frontiers in pharmacology · 2026Article
- From Fluid Responsiveness to Prognosis: The Emerging Role of Point-of-Care Echocardiography in Sepsis.Diagnostics (Basel, Switzerland) · 2025Review
- Development and internal-external validation of a risk prediction nomogram for secondary myocardial injury in traumatic brain injury.Frontiers in neurologyArticle
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Abstract
Objective: The objective of this study was to systematically identify and evaluate scoring systems that predict the prognosis of patients with sepsis-induced myocardial injury (SIMI). Methods: Data were retrieved from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database. Logistic and Cox regression analyses were conducted to identify risk factors associated with 28-day mortality in patients with sepsis-induced myocardial injury (SIMI). The prognostic performance of the scoring systems was comprehensively assessed using receiver operating characteristic (ROC) curves, Kaplan-Meier survival and decision curve analysis (DCA). Results: Logistic regression analysis showed that Acute Physiology Score III (APSIII) (Odds Ratio [OR] =1.011, 95% Confidence Interval [CI] 1.002-1.018, P=0.005), Sequential Organ Failure Assessment (SOFA) (OR =1.097, 95% CI 1.045-1.144, P<0.001), and Charlson Comorbidity Index (CHARLSON) (OR=1.095, 95% CI 1.048-1.145, P=0.036) were independent risk factors for 28-day mortality in SIMI patients. Cox regression analysis confirmed that SOFA (HR=1.082, 95% CI 1.054- 1.111, P<0.001), APSIII (HR=1.010, 95% CI 1.005-1.015, P<0.001), and CHARLSON (HR=1.044, 95% CI 1.012-1.077, P=0.007) were independent risk factors. ROC curve analysis showed that SOFA (AUC=0.685, 95% CI 0.663-0.707) and APSIII (AUC=0.683, 95% CI 0.662-0.705) had significantly higher AUC values compared to other scoring systems. DCA results showed that APSIII and SOFA had better net benefit than other scoring systems. Conclusions: The SOFA and APSIII scores effectively identified high-risk patients with SIMI, providing evidence-based support for early clinical intervention.
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