ArticleRegenerative biomaterials2025
Strontium-incorporated hydroxyapatite nanocomposites promoting bone formation and angiogenesis by modulating M2 macrophage polarization in the bone microenvironment.
Article in Regenerative biomaterials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Article
- Multi-biomimetic poly(amino acid)-based Janus membrane integrating barrier and osteoinductive functions for cranial bone regeneration.Materials today. Bio · 2026Article
- Innovative Hydroxyapatite-Hydrogel Composites for Cartilage Regeneration.Gels (Basel, Switzerland) · 2026Review
- Metal-Substituted Hydroxyapatite Nanoparticles as Antimicrobial and Osteogenic Biomaterials for Hard-Tissue Applications.Materials (Basel, Switzerland) · 2026Review
- Adaptive hydrogel platforms for infected bone defect repair: microenvironmental responsiveness, osteoimmunomodulation, and regenerative remodeling.Frontiers in bioengineering and biotechnology · 2026Review
- Beyond labeling: differential AcRegenerative biomaterials · 2026Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The treatment of osteoporosis is urgently needed in the clinic. Hydroxyapatite (HAP) has a bone-inducing ability on osteogenic differentiation. Especially, the presence of strontium component in HAP nanoparticles may improve the positive effect on bone regeneration and avoid undesirable bone resorption. However, the incorporating concentrations of strontium still need to be elucidated to balance the osteogenic function and side effects. Herein, a series of strontium-incorporated HAP nanocomposites (Srx-HAP) with different Sr incorporating molar ratio concentrations (0%, 1%, 2%, 5%, 10%, 20%, 50%, 80% and 100%) have been prepared by a simple hydrothermal route. The Srx-HAP samples exhibited uniform and well-dispersed rod-like morphology, mesoporous structure, eminent degradability and good biocompatibility. In particular, Sr20-HAP exhibited prominent advantages in osteogenic differentiation and mineralization of pre-osteoblasts cell line MC3T3-E1. Sr20-HAP nanoparticles were highly effective in enhancing the bone formation in the rat model of postmenopausal osteoporosis compared to the ovariectomy group. In addition, Sr20-HAP nanoparticles could regulate macrophage polarization to M2 type
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