ReviewCureus2025
The Role of the Wnt/β-Catenin Signaling Pathway in the Pathogenesis and Treatment of Spinal Cord Injury: A Review of the Latest Experimental Data.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- The Canonical Wnt Surrogate Agonist scFv-Dkk1c Ameliorates Spinal Cord Injury in Rats.Molecular neurobiology · 2026Article
- Exosome-derived ncRNAs and proteins: inflammation regulatory mechanisms and biomarker potential in spinal cord injury.Frontiers in molecular biosciences · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spinal cord injury (SCI) is a debilitating condition with a high incidence, leading to irreversible motor, sensory, and autonomic dysfunctions. Despite significant advances in understanding the pathophysiology of SCI, effective therapeutic strategies for regeneration remain elusive. The Wnt/β-catenin signaling pathway has emerged as a key player in various developmental and pathological processes, including tissue regeneration, neuroprotection, and inflammation, all of which are crucial in SCI. The aim of this paper is to review the current understanding of the Wnt/β-catenin signaling pathway in the pathogenesis of SCI and its potential as a therapeutic target for improving recovery after SCI. The Wnt/β-catenin signaling pathway has a distinctive role in SCI pathogenesis, encompassing regulation of inflammation, apoptosis, glial scar, axonal repair and regeneration, and angiogenesis. Many treatment modalities, such as pharmaceutical administration, stem cell transplantation, gene therapy, electric stimulation, and the use of biomaterials and exosomes, exert beneficial effects in SCI animal models by interacting with the Wnt/β-catenin signaling pathway. The Wnt/β-catenin signaling pathway plays a multifaceted role in the pathogenesis of SCI and offers a promising avenue for therapeutic intervention. Its effects depend on the specific Wnt ligands involved, the injury stage, and the cellular environment. Precisely modulating Wnt signaling could be a promising therapeutic strategy for enhancing spinal cord repair and functional recovery after injury. Although significant progress has been made, further studies are needed to improve our understanding of its context-dependent effects and to address therapeutic challenges.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.