ArticleCureus2025
Successful Outcome in a Geriatric Patient With Giant Dedifferentiated Liposarcoma of the Lower Extremity: A Case Report.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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3 authors.
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Abstract
Liposarcomas are rare malignant soft tissue tumors; the dedifferentiated liposarcoma (DDL) subtype accounts for 6% of all soft tissue sarcomas. This tumor can develop de novo or transition from an atypical lipomatous tumor (ALT), occurring more frequently in the retroperitoneum; presentation in the extremities is uncommon. This subtype behaves aggressively, leading to local recurrence, metastasis, and a poor disease-free survival rate if treated improperly. We present the case of a 70-year-old female with a history of a giant soft tissue mass of one year of growth, with limited range of motion of her right lower extremity and edema. Initial histological analysis identified the mass as a well-differentiated liposarcoma/ALT. Post-surgical histological examination revealed a DDL, measuring 28 cm x 24 cm x 21 cm. Dedifferentiation from a well-differentiated tumor happens in approximately 10% of cases. Age, location, size, histological subtype, and presence of metastasis are the most important prognostic factors. Early suspicion of liposarcoma is paramount when facing a large, growing tumor in soft tissues; histological examination must be done to offer the proper treatment.
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