ArticleAlzheimer's & dementia (Amsterdam, Netherlands)
Sex and ethnicity in early-onset Alzheimer's disease biomarkers and global function.
Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Lipid metabolism, neuroinflammation, and oxidative stress in Alzheimer disease: an integrated mechanistic review.Acta neurologica Belgica · 2026Review
- Criterion and convergent validity of plasma biomarkers in early-onset Alzheimer's disease: Initial findings from LEADS.Alzheimer's & dementia (Amsterdam, Netherlands)Article
- Sex and ethnicity in early-onset Alzheimer's disease biomarkers and global function.Alzheimer's & dementia (Amsterdam, Netherlands)Article
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13 authors.
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Abstract
introductionEarly-onset Alzheimer's disease (EOAD) may have distinct biomarker and clinical features from late-onset AD (LOAD). EOAD is understudied in ethnically heterogeneous populations.
methodsWe studied EOAD (
resultsAD-related biomarkers and global function were consistently worse in EOAD than EOnonAD and CN, and similar or worse than LOAD. Among EOAD, younger age related to greater amyloid burden among non-Hispanic/Latino individuals only. AD-related biomarker changes were more severe in females than males among non-Hispanic/Latino EOAD, but more severe among males in Hispanic/Latino EOAD. DISCUSSION: The biological and clinical features of EOAD may differ by sex and ethnicity. Highlights: Alzheimer's disease (AD) biomarkers and global functional measures were measured in Hispanic and non-Hispanic individuals with early-onset AD (EOAD).Overall, AD-related biomarkers and global function were consistently worse in EOAD than non-AD cognitive decline and controls, and similar or worse than late-onset AD.Younger age related to greater amyloid burden among non-Hispanic EOAD, but not Hispanic EOAD.Hispanic EOAD males had more severe changes than females, contrasting findings in non-Hispanic EOAD (females more severe than males).
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