ReviewFrontiers in pharmacology2025
Sweroside: unveiling broad therapeutic potential-from mechanistic insights to clinical potential.
Review in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Flavonoids fromJournal of enzyme inhibition and medicinal chemistry · 2026Article
- Development of Wedelia (Current issues in molecular biology · 2026Article
- Systemic Exposure and Multicomponent Pharmacokinetics of Mailuoning Oral Liquid: Integrated Ultra-High-Performance Liquid Chromatography-High-Resolution Mass Spectrometry Profiling and Ultra-High-Performance Liquid Chromatography-Tandem Mass Spectrometry Quantification.Journal of separation science · 2026Article
- Unlocking the Functional Potential ofBiomolecules · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Sweroside, a secoiridoid glycoside abundantly present in medicinal plants, has garnered significant attention due to its diverse bioactivities, including anti-inflammatory, antioxidant, hepatoprotective, antidiabetic, antibacterial, and anticancer effects. Additionally, it exhibits promising potential in neuroprotection and dermatological health. Purpose: This review aims to provide a comprehensive analysis of Sweroside, focusing on its sources, biosynthetic pathways, pharmacodynamic mechanisms, and therapeutic potential. The insights presented aim to facilitate the development of novel pharmacotherapies and advance precision medicine. Methods: A systematic review of the literature was conducted using databases such as PubMed, Web of Science, and Google Scholar. The study examined Sweroside's sources, distribution, biosynthesis, pharmacodynamics, and therapeutic applications. Challenges in its clinical translation were also evaluated, with proposed strategies to enhance bioavailability. Results: Sweroside modulates critical signaling pathways, such as NF-κB, mTOR, MAPK, and PI3K/Akt, and their molecular substrates, contributing to its therapeutic effects across various pathological conditions. Preclinical studies demonstrate its efficacy in treating hepatic disorders, osteoporosis, cardiovascular diseases, and neurological dysfunctions. It also shows promise in neuroprotection and dermatological health. However, clinical translation is hindered by its low bioavailability and rapid metabolic degradation. Conclusion: Sweroside is a versatile natural metabolite with multi-target therapeutic potential, positioning it as a promising candidate for next-generation pharmacotherapies. To realize its clinical potential, future research should prioritize optimizing its pharmacokinetics, including enhancing bioavailability and developing advanced drug delivery systems. Further investigation into its molecular mechanisms and intracellular targets across diverse pathological conditions is essential. Sweroside's integration into precision medicine offers significant opportunities for addressing chronic and complex diseases.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.