ArticleFrontiers in pharmacology2025
The effects of Shenkang suppository on kidney function and gut microbiota in nondialysis patients with chronic kidney disease stages 3-4: A randomized controlled trial.
Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Effects of Shenkang for chronic kidney disease: a propensity score matched with network pharmacology analysis.Renal failure · 2025Article
- Total flavonoids fromFrontiers in medicine · 2025Article
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7 authors.
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Abstract
Background: Chronic kidney disease (CKD) patients have high prevalence and mortality rates; however, current treatment options remain limited. The Shenkang suppository (SKS) is a traditional Chinese medicine used in the clinical management of CKD. Increasing evidence suggests a close relationship between the gut microbiome and CKD. We aimed to investigate the impact of SKS on kidney function and the gut microbiota in CKD stage 3-4 patients. Methods: It's a single-center randomized controlled trial (n = 80). CKD stage 3-4 patients were randomly assigned at a 1:1 ratio to either the control group (n = 40) or the SKS group (n = 40) and followed for 8 weeks. Baseline data, clinical indicators, kidney markers, and stool samples were obtained from participants before and after treatment. The bacterial DNA was isolated from fecal samples and analyzed via high-throughput 16S rRNA sequencing. Results: A total of 34 patients in the SKS group and 36 in the control group completed the study. Kidney function in the control group significantly worsened after 8 weeks ( Conclusion: SKS could delay the progression of kidney function in CKD stage 3-4 patients, possibly by modulating the dysbiosis of the gut microbiota. The close associations between certain gut microbiota and clinical kidney function indicators suggest that the gut microbiota could serve as a new therapeutic target for CKD. Clinical Trial Registration: https://www.chictr.org.cn/, Chinese Clinical Trial Registry Identifier: ChiCTR2200058493.
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