ArticleOpen forum infectious diseases2025
Ventriculitis: A Retrospective Cohort Study of Clinical Features, Outcomes and Device Management Practices.
Article in Open forum infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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16 authors.
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Abstract
Background: Ventriculitis is a severe central nervous system infection, often secondary to intraventricular device use or neurosurgical procedures, with high morbidity and mortality. Diagnostic criteria remain debated, and treatment strategies lack standardization. Methods: We conducted a retrospective cohort study from 2014 to 2022 to describe the clinical characteristics, microbiological profile, treatment strategies, and outcomes of ventriculitis at a tertiary care center. Additionally, we compared outcomes before and after the implementation of an updated intraventricular device management protocol. Results: A total of 403 positive cerebrospinal fluid cultures were identified during the study period. Among these, 87 fulfilled clinical and microbiological criteria for ventriculitis. Healthcare-associated cases predominated (73 [83.9%]), with neurosurgical interventions (72 [82.8%]) and external ventricular drain use (54 [62.1%]) as the most prevalent risk factors. The most common pathogens were coagulase-negative staphylococci (42 [48.3%]), particularly Conclusions: Ventriculitis remains a complex and life-threatening condition with considerable diagnostic and management challenges. Our findings suggest that standardized intraventricular device care protocols may contribute to improved outcomes, although further evaluation is needed.
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