Evidence map›Paper›PMID 40799759›Full record

ArticleResearch square2025

Genetic depletion of early autophagy protein ATG13 impairs mitochondrial energy metabolism, augments oxidative stress, induces the polarization of macrophages to M1 inflammatory mode, and compromises myelin integrity in skeletal muscle.

Mubaraq A Toriola, Emma Timlin, Sarojini Bulbule, Amy Reyes, Omolola Mary Adedeji, C Gunnar Gottschalk, Animesh Barua, Leggy A Arnold, Avik Roy

Abstract readPreprint
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Mubaraq A ToriolaUniversity of Wisconsin-Milwaukee.
Emma TimlinUniversity of Wisconsin-Milwaukee.
Sarojini BulbuleSimmaron Research INC.
Amy ReyesSimmaron Research INC.
Omolola Mary AdedejiUniversity of Wisconsin-Milwaukee.
C Gunnar GottschalkSimmaron Research INC.
Animesh BaruaSimmaron Research INC.
Leggy A ArnoldUniversity of Wisconsin-Milwaukee.
Avik RoySimmaron Research INC.

Funding

ATG13: A new player in ME/CFSR21NS129021 · NINDS · SIMMARON RESEARCH INC · PI ROY, AVIK · 2023 to 2024
$450k
NINDS NIH HHS R21 NS129021
6 · The paper itself

Abstract

M1 macrophage activation is crucial in chronic inflammatory diseases, yet its molecular mechanism is unclear. Our study shows that hemizygous deletion of early autophagy gene

Identifiers

PMID40799759
PMCPMC12340908

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.