Evidence map›Paper›PMID 40799750›Full record

ArticleResearch square2025

Persistent cortical excitatory neuron dysregulation in adult

Cesar P Canales, Stephanie A Lozano, Nicholas A Frost, Karol Cichewicz, Wellington Amaral, Nicolas Seban, Ethan Fenton, Ayanna Wade, Nickolas Chu, Emily Smith and 21 more

Abstract readPreprint
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Cesar P CanalesUC Davis Center for Neuroscience, Davis, CA 95618, USA.ORCID 0000-0003-2505-8367
Stephanie A LozanoUC Davis Center for Neuroscience, Davis, CA 95618, USA.
Nicholas A FrostUniversity of Utah, Department of Neurology, Salt Lake City, Utah, United States of America.ORCID 0000-0002-2270-643X
Karol CichewiczUC Davis Center for Neuroscience, Davis, CA 95618, USA.
Wellington AmaralThe M.I.N.D. Institute, UC Davis, Sacramento, CA, USA.ORCID 0000-0003-4558-1761
Nicolas SebanUC Davis Center for Neuroscience, Davis, CA 95618, USA.
Ethan FentonUC Davis Center for Neuroscience, Davis, CA 95618, USA.
Ayanna WadeUC Davis Center for Neuroscience, Davis, CA 95618, USA.
Nickolas ChuUC Davis Center for Neuroscience, Davis, CA 95618, USA.ORCID 0000-0002-9860-7788
Emily SmithUC Davis Center for Neuroscience, Davis, CA 95618, USA.
Cory ArdekaniUC Davis Center for Neuroscience, Davis, CA 95618, USA.
Samuel FrankThe M.I.N.D. Institute, UC Davis, Sacramento, CA, USA.
Jeffrey BennettThe M.I.N.D. Institute, UC Davis, Sacramento, CA, USA.ORCID 0000-0002-3255-5663
Pierre LavenexLaboratory of Brain and Cognitive Development, Institute of Psychology, University of Lausanne, Switzerland.ORCID 0000-0002-9278-1312
Aspen Kopley-SmithUC Davis Center for Neuroscience, Davis, CA 95618, USA.
Darlene RahbarianUC Davis Center for Neuroscience, Davis, CA 95618, USA.
Melissa CoreaUC Davis Center for Neuroscience, Davis, CA 95618, USA.
Daniela PerlaUC Davis Center for Neuroscience, Davis, CA 95618, USA.
Liam DavisUC Davis Center for Neuroscience, Davis, CA 95618, USA.
Jiyuan ZhuUC Davis Center for Neuroscience, Davis, CA 95618, USA.
Rebecca OrtizUC Davis Center for Neuroscience, Davis, CA 95618, USA.
Paris BeauregardUC Davis Center for Neuroscience, Davis, CA 95618, USA.
Sarah MorseUC Davis Center for Neuroscience, Davis, CA 95618, USA.
Jacob BakerDepartment of Molecular, Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, CA 95064, USA.
Jingqi SunDepartment of Molecular, Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, CA 95064, USA.
Boxuan MaDepartment of Molecular, Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, CA 95064, USA.
Ju LuDepartment of Molecular, Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, CA 95064, USA.
Vikaas S SohalDepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco | Weill Institute for Neurosciences, University of California, San Francisco | Kavli Institute for Fundamental Neuroscience, University of California, San Francisco.ORCID 0000-0002-2238-4186
David G AmaralUC Davis Center for Neuroscience, Davis, CA 95618, USA.
Yi ZuoDepartment of Molecular, Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, CA 95064, USA.ORCID 0000-0001-9020-0003
Alex S NordUC Davis Center for Neuroscience, Davis, CA 95618, USA.ORCID 0000-0003-4259-7514

Funding

UC Davis MCB T32 Administrative Supplement to Recognize Excellence in Diversity, Equity, Inclusion, and Accessibility (DEIA) MentorshipT32GM007377 · NIGMS · UNIVERSITY OF CALIFORNIA DAVIS · PI CHEDIN, FREDERIC LOUIS · 1985 to 2023
$9.9M
Interdisciplinary Training for Autism Researchers(RMI)T32MH073124 · NIMH · UNIVERSITY OF CALIFORNIA DAVIS · PI Stephen Charles Noctor, Christine Wu Nordahl · 2004 to 2026
$6.8M
How is anxiety-related information relayed across hippocampal-prefrontal circuitsR01MH117961 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KHEIRBEK, MAZEN A, SOHAL, VIKAAS SINGH · 2019 to 2022
$2.3M
Causal biology of Chd8 haploinsufficiency in complex brain disordersR01MH120513 · NIMH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI NORD, ALEXANDER · 2019 to 2023
$2.3M
Abnormal Prefrontal Network Structure Underlying Anxiety in AutismK08NS105938 · NINDS · UNIVERSITY OF UTAH · PI FROST, NICHOLAS ALONZO · 2018 to 2022
$1.0M
Mapping the cellular impacts of Chd8 haploinsufficiency and characterizing microglial activity in Chd8 mutant miceF31HD113328 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Stephanie Lozano · 2024 to 2026
$118k
Chd8 Dosage-Sensitivity in Mature Neurons Contributes to ASD-Associated PathologyF31MH119789 · NIMH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI WADE, ALEXANDRIA AYANNA · 2019 to 2020
$56k
NICHD NIH HHS F31 HD113328NIGMS NIH HHS T32 GM007377NIMH NIH HHS F31 MH119789NIMH NIH HHS R01 MH117961NIMH NIH HHS R01 MH120513NIMH NIH HHS T32 MH073124NINDS NIH HHS K08 NS105938
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID40799750
PMCPMC12340929

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.