ArticleResearch square2025
Exploring risk and protective urban environmental factors on mental health through exposure network mapping.
Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundUrbanicity has been revealed to carry a higher risk of experiencing mental health issues. However, the factors in urban environments that pose risks or protective impacts on mental health remain unclear.
methodsBased on eight literature-based datasets and one validation dataset, this study introduced a new technique termed exposure network mapping (ENM) to explore the impacts of urbanicity on brain networks, identify the potential risk urban environmental factors, and examine whether healthy lifestyle habits may provide protective effects on mental health.
resultsUsing ENM, this study consolidated existing heterogenous coordinates of urbanicity into a common, significant and replicable network, which primarily located in middle frontal gyrus, orbital gyrus and anterior cingulate gyrus. When conducting ENM analysis using coordinates of five representative factors (i.e., air pollution, noise pollution, income, stress, and green space), only seeds derived from stress significantly converged to a common network, highlighting orbital gyrus, caudate, anterior and middle cingulate gyrus, hippocampus and middle frontal gyrus. The ENM-stress map further exhibited the highest correlation with both the ENM-urbanicity map(
conclusionThis study highlights the potential risks of urbanicity and stress on brain networks, as well as the protective role of healthy habitats-particularly sleep-in safeguarding mental health, which may offer new insights for preventing mental health issues in urban environments.
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