Evidence map›Paper›PMID 40799732›Full record

ArticleResearch square2025

Nuclear Envelope Membrane Protein 1 plays crucial and conserved roles in female meiosis.

Bilal Ahmad Hakim, Yonit Tsatskis, Ling Zhang, Esther Choi, Ying Zhang, Didier Hodzic, Que Wu, MuYun Zhang, Maryam Pashei, Kyungwon Ha and 4 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Bilal Ahmad HakimDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0009-0005-2794-3388
Yonit TsatskisCell & Systems Biology Program, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.ORCID 0000-0003-2580-0728
Ling ZhangDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Esther ChoiMagee-Womens Research Institute, University of Pittsburgh, Pittsburgh, PA, USA.
Ying ZhangLunenfeld Tanenbaum Research Institute, Sinai Health Systems, Toronto, ON M5G 1X5, Canada.
Didier HodzicDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Que WuLunenfeld Tanenbaum Research Institute, Sinai Health Systems, Toronto, ON M5G 1X5, Canada.
MuYun ZhangLunenfeld Tanenbaum Research Institute, Sinai Health Systems, Toronto, ON M5G 1X5, Canada.
Maryam PasheiLunenfeld Tanenbaum Research Institute, Sinai Health Systems, Toronto, ON M5G 1X5, Canada.
Kyungwon HaLunenfeld Tanenbaum Research Institute, Sinai Health Systems, Toronto, ON M5G 1X5, Canada.
Julie A BrillCell & Systems Biology Program, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada.ORCID 0000-0002-5925-9901
Miguel Angel Brieño-EnríquezMagee-Womens Research Institute, University of Pittsburgh, Pittsburgh, PA, USA.
Andrea JurisicovaLunenfeld Tanenbaum Research Institute, Sinai Health Systems, Toronto, ON M5G 1X5, Canada.
Helen McNeillDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0003-1126-5154

Funding

Dissecting the function of Nemp1, a nuclear envelope protein critical for mammalian fertilityR01HD108639 · NICHD · WASHINGTON UNIVERSITY · PI Helen McNeill · 2023 to 2026
$2.3M
NICHD NIH HHS R01 HD108639
6 · The paper itself

Abstract

Female germ cells must preserve the integrity of their genome and generate genetic diversity via meiotic recombination. This challenging process, which occurs during fetal life, is error prone. Highly conserved checkpoint pathways detect errors in recombination and DNA damage, inducing the death of defective oocytes. Nuclear Envelope Membrane Protein (NEMP) homologs are highly conserved inner nuclear membrane proteins which are critical for fertility in flies, worms, fish and mice, and mechanically support the nuclear envelope. However, why NEMP homologs are required for fertility is still unclear. Using both

Identifiers

PMID40799732
PMCPMC12340924

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.