ArticleImaging neuroscience (Cambridge, Mass.)2023
Unique information from common diffusion MRI models about white-matter differences across the human adult lifespan.
Article in Imaging neuroscience (Cambridge, Mass.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- High-Resolution Diffusion Kurtosis Imaging of Hippocampus Subfields Across the Healthy Lifespan.NMR in biomedicine · 2026Article
- The 5-HT1A receptor antagonist WAY-100635 maleate promotes retinal ganglion cell differentiation and protects the retino-visual circuits.Communications medicine · 2026Article
- Plasma complex lipids in relation to cortical thickness and brain volumes: results from the population-based Rhineland study.Lipids in health and disease · 2026Article
- Frontal Vulnerability versus Temporal Resilience within the Core Language Network: Neuro-compensatory Mechanisms Underline Differential Language Aging Trajectories.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- A systematic study on the integration of MRI connectivity metrics for Alzheimer's diagnosis, staging, and cognitive decline prediction.Frontiers in neuroimaging · 2026Article
- Lifespan Normative Modeling of Brain Microstructure.bioRxiv : the preprint server for biology · 2025Article
- Birefringence microscopy enables rapid, label-free quantification of myelin debris following induced cortical injury.Neurophotonics · 2025Article
- Microstructural Changes in Aging Hippocampal Pathways: Insights From the HCP-Aging Diffusion MRI Study.Human brain mapping · 2025Article
- Pulse Pressure Impairs Cognition via White Matter Disruption.Hypertension (Dallas, Tex. : 1979) · 2025Article
- Complementary MR measures of white matter and their relation to cardiovascular health and cognition.Scientific reports · 2025Article
- Mapping the microstructure of human cerebral cortex in vivo with diffusion MRI.Communications biology · 2025Article
- Neuroanatomical Changes in the Stopping Network Across the Adult Lifespan Assessed With Quantitative and Diffusion MRI.Human brain mapping · 2025Article
- Non-Invasive Diagnosis and Monitoring of Diabetic Nephropathy: Assessment of Renal Function and Fibrosis by Diffusion Kurtosis Imaging.International journal of general medicine · 2025Article
- Impact of truncating diffusion MRI scans on diffusional kurtosis imaging.Magma (New York, N.Y.) · 2024Article
- Distinct Longitudinal Brain White Matter Microstructure Changes and Associated Polygenic Risk of Common Psychiatric Disorders and Alzheimer's Disease in the UK Biobank.Biological psychiatry global open science · 2024Article
- The trouble with free-water elimination using single-shell diffusion MRI data: A case study in ageing.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- White matter tract microstructure, macrostructure, and associated cortical gray matter morphology across the lifespan.bioRxiv : the preprint server for biology · 2023Article
- White matter tract microstructure, macrostructure, and associated cortical gray matter morphology across the lifespan.Imaging neuroscience (Cambridge, Mass.) · 2023Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diffusion Magnetic Resonance Imaging (dMRI) is sensitive to white matter microstructural changes across the human lifespan. Several models have been proposed to provide more sensitive and specific metrics than those provided by the conventional Diffusion Tensor Imaging (DTI) analysis. However, previous results using different metrics have led to contradictory conclusions regarding the effect of age on fibre demyelination and axonal loss in adults. Moreover, it remains unclear whether these metrics provide distinct information about the effects of age, for example, on different white-matter tracts. To address this, we analysed dMRI data from 651 adults approximately uniformly aged from 18 to 88 years in the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) cohort, using six dMRI metrics: Fractional Anisotropy (FA) from standard DTI; Mean Signal Diffusion (MSD) and Mean Signal Kurtosis (MSK) from Diffusional Kurtosis Imaging (DKI) applied to directional averaged diffusion-weighted signals; and Neurite Density Index (NDI), Orientation Dispersion Index (ODI), and isotropic Free water volume fraction (F
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