Evidence map›Paper›PMID 40799641›Full record

ArticleFrontiers in immunology2025

The role of HLA-G in primary biliary cholangitis and response to therapy.

Michela Miglianti, Stefano Mocci, Roberto Littera, Giancarlo Serra, Cinzia Balestieri, Maria Conti, Francesco Pes, Silvia Deidda, Michela Lorrai, Caterina Mereu and 14 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Michela Miglianti *Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.
Stefano Mocci *Medical Genetics, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.
Roberto Littera *AART-ODV (Association for the Advancement of Research Transplantation), Cagliari, Italy.
Giancarlo SerraDepartment of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.
Cinzia BalestieriGastroenterology Unit, ARNAS Brotzu, Cagliari, Italy.
Maria ContiGastroenterology Unit, ARNAS Brotzu, Cagliari, Italy.
Francesco PesGastroenterology Unit, ARNAS Brotzu, Cagliari, Italy.
Silvia DeiddaPneumology Unit, R. Binaghi Hospital, ASSL Cagliari, Cagliari, Italy.
Michela LorraiMedical Genetics, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.
Caterina MereuMedical Genetics, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.
Michela MurgiaMedical Genetics, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.
Celeste SannaMedical Genetics, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.
Alessia MasciaOncology and Molecular Pathology Unit, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
Francesca SeddaOncology and Molecular Pathology Unit, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
Irena Duś-IlnickaDepartment of Oral Pathology, Wrocław Medical University, Wrocław, Poland.
Selene CipriAART-ODV (Association for the Advancement of Research Transplantation), Cagliari, Italy.
Mauro Giovanni CartaDepartment of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.
Sara LaiMedical Genetics, R. Binaghi Hospital, ASL Cagliari, Cagliari, Italy.
Erika GiuressiMedical Genetics, R. Binaghi Hospital, ASL Cagliari, Cagliari, Italy.
Maurizio MelisAART-ODV (Association for the Advancement of Research Transplantation), Cagliari, Italy.
Teresa ZolfinoGastroenterology Unit, ARNAS Brotzu, Cagliari, Italy.
Sabrina GiglioMedical Genetics, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.
Andrea PerraAART-ODV (Association for the Advancement of Research Transplantation), Cagliari, Italy.
Luchino ChessaDepartment of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Primary biliary cholangitis (PBC) is a rare autoimmune liver disease involving bile duct damage and fibrosis. This study explores the role of HLA-G, an immunomodulatory molecule crucial for immune tolerance, in PBC pathogenesis and treatment. Methods: A cohort of 166 PBC patients from Sardinia was compared to 180 healthy controls and 205 autoimmune hepatitis type 1 (AIH-1) patients. Plasma soluble HLA-G (sHLA-G) levels, Results: The UTR-1 haplotype was significantly more frequent in PBC patients than in controls (48.2% vs 34.3%, Pc= 0.0018). The extended haplotype Discussion: These findings suggest HLA-G variants, especially

Indexed as

HLA-G AntigensLiver Cirrhosis, BiliaryUrsodeoxycholic AcidAdultAgedAllelesBiomarkersFemaleGenetic Predisposition to DiseaseHaplotypesHumansMaleMiddle AgedTreatment OutcomeBiomarkersHLA-G AntigensUrsodeoxycholic Acidautoimmune diseasesHLA-Gprimary biliary cholangitisSardinia (Italy)ursodeoxicholic acid

Identifiers

PMID40799641
PMCPMC12339529

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.