Evidence map›Paper›PMID 40799577›Full record

ArticlebioRxiv : the preprint server for biology2025

CCDC32 collaborates with the membrane to assemble the AP-2 clathrin adaptor complex.

Dillon E Sloan, Ariel Matthews, Haruaki Yanagisawa, Tanita Tedamrongwanish, Kevin Cannon, Jake Simmons, Garrett Chappell, Nathan I Nicely, Rebecca Berlow, Masahide Kikkawa and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Dillon E SloanDepartment of Biochemistry and Biophysics, UNC Chapel Hill School of Medicine; Chapel Hill, NC 27599, USA.ORCID 0000-0001-6065-176X
Ariel MatthewsDepartment of Biochemistry and Biophysics, UNC Chapel Hill School of Medicine; Chapel Hill, NC 27599, USA.ORCID 0000-0002-7845-0402
Haruaki YanagisawaDepartment of Cell Biology and Anatomy, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.ORCID 0000-0003-0313-2343
Tanita TedamrongwanishDepartment of Biochemistry and Biophysics, UNC Chapel Hill School of Medicine; Chapel Hill, NC 27599, USA.ORCID 0009-0004-7500-6404
Kevin CannonDepartment of Biochemistry and Biophysics, UNC Chapel Hill School of Medicine; Chapel Hill, NC 27599, USA.ORCID 0000-0002-6648-3442
Jake SimmonsDepartment of Biochemistry and Biophysics, UNC Chapel Hill School of Medicine; Chapel Hill, NC 27599, USA.ORCID 0009-0003-6281-0391
Garrett ChappellDepartment of Biochemistry and Biophysics, UNC Chapel Hill School of Medicine; Chapel Hill, NC 27599, USA.ORCID 0000-0002-0078-1498
Nathan I NicelyDepartment of Pharmacology, UNC Chapel Hill School of Medicine; Chapel Hill, NC 27599, USA.ORCID 0000-0002-0025-2377
Rebecca BerlowDepartment of Biochemistry and Biophysics, UNC Chapel Hill School of Medicine; Chapel Hill, NC 27599, USA.ORCID 0000-0003-1934-0139
Masahide KikkawaDepartment of Cell Biology and Anatomy, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.ORCID 0000-0001-7656-8194
Richard W BakerDepartment of Biochemistry and Biophysics, UNC Chapel Hill School of Medicine; Chapel Hill, NC 27599, USA.ORCID 0000-0003-1136-6000

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI David Darr · 1985 to 2026
$201.5M
Molecular mechanisms of endocytic initiation and cargo selectionR35GM150960 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Richard Wayne Baker · 2023 to 2026
$1.6M
Molecular and Cellular Biophysics Training GrantT32GM148376 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Matthew R Redinbo, Qi Zhang · 2024 to 2026
$1.4M
Molecular mechanism of CCDC32 in Cardiofacioneurodevelopmental syndromeF31DE034311 · NIDCR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SLOAN, DILLON · 2024 to 2025
$75k
NCI NIH HHS P30 CA016086NIDCR NIH HHS F31 DE034311NIGMS NIH HHS R35 GM150960NIGMS NIH HHS T32 GM148376
6 · The paper itself

Abstract

Cells have evolved a variety of assembly chaperones to aid in the difficult process of forming macromolecular complexes in a crowded cytoplasm. Assembly of adaptor protein complex 2 (AP-2), the primary cargo adaptor in clathrin-mediated endocytosis, is regulated by the chaperones AAGAB and CCDC32, whose deletion causes loss of all AP-2 subunits

Identifiers

PMID40799577
PMCPMC12340815

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.