Evidence map›Paper›PMID 40799576›Full record

ArticlebioRxiv : the preprint server for biology2025

Systemic Translocation of

Da Cheng, Zhenwu Luo, Wangbin Ning, Sonya L Heath, Magnus Gisslen, Richard W Price, Ruth Adekunle, Tabinda Salman, Douglas Johnson, John E McKinnon and 3 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Da Cheng
Zhenwu Luo
Wangbin Ning
Sonya L Heath
Magnus Gisslen
Richard W Price
Ruth Adekunle
Tabinda Salman
John E McKinnon
Lishomwa C NdhlovuORCID 0000-0001-5427-4187
Wenhui Hu

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Anti-CD4 autoantibodies in people with HIV (PWH) receiving suppressive antiretroviral therapy (ART) appear to prevent CD4+ T cell reconstitution, yet the mechanisms underlying their production remain unclear. Emerging evidence implicates Methods: Plasma from 32 ART-naive PWH, 53 ART-treated PWH, and 32 HIV- negative controls was analyzed for IgG autoantibodies and markers of Results: Among 87 autoantibodies, 40% were elevated in ART-naive PWH and largely normalized by ART; however, anti-CD4 IgGs remained elevated in PWH on ART. Anti- CD4 IgG levels inversely correlated with CD4+ T cell counts in ART-treated PWH and positively with Conclusion:

Identifiers

PMID40799576
PMCPMC12340865

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.