Evidence map›Paper›PMID 40799568›Full record

ArticlebioRxiv : the preprint server for biology2025

Defined human tri-lineage brain microtissues.

Takeshi Uenaka, Sascha Jung, Ishan Kumar, Kit Vodehnal, Mohit Rastogi, Yongjin Yoo, Mark Koontz, Christian Thome, Wanhua Li, Tamara Chan and 18 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Takeshi UenakaInstitute for Stem Cell Biology & Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Sascha JungCIC bioGUNE-BRTA (Basque Research and Technology Alliance), Bizkaia Technology Park, 801 Building, Derio, 48160 Spain.
Ishan KumarInstitute for Stem Cell Biology & Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Kit VodehnalInstitute for Stem Cell Biology & Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Mohit RastogiInstitute for Stem Cell Biology & Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Yongjin YooInstitute for Stem Cell Biology & Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Mark KoontzDepartment of Ophthalmology, School of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Christian ThomeInstitute for Stem Cell Biology & Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.ORCID 0000-0002-3344-8683
Wanhua LiInstitute for Stem Cell Biology & Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Tamara ChanInstitute for Stem Cell Biology & Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Erin M GreenInstitute for Stem Cell Biology & Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Kirill ChesnovInstitute for Stem Cell Biology & Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Zijun SunDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Shuyuan ZhangDepartment of Biology, Stanford University, Stanford, CA, USA.ORCID 0000-0002-6220-5998
Jinzhao WangInstitute for Stem Cell Biology & Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Anthony VenidaDepartment of Genetics, Stanford University, Stanford, CA, USA.
Anne-Laure Mahul MellierLaboratory of Molecular and Chemical Biology of Neurodegeneration, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Micaiah AtkinsDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, CA, USA.
Meredith JackrelDepartment of Chemistry, Washington University in St. Louis, St. Louis, MO, USA.ORCID 0000-0003-4406-9504
Jan M SkotheimDepartment of Biology, Stanford University, Stanford, CA, USA.
Tony Wyss-CorayDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, CA, USA.ORCID 0000-0001-5893-0831
Monther Abu-RemailehDepartment of Genetics, Stanford University, Stanford, CA, USA.ORCID 0000-0003-3772-0477
Hilal A LashuelLaboratory of Molecular and Chemical Biology of Neurodegeneration, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Michael C BassikDepartment of Genetics, Stanford University, Stanford, CA, USA.
Thomas C SüdhofDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Antonio Del SolCIC bioGUNE-BRTA (Basque Research and Technology Alliance), Bizkaia Technology Park, 801 Building, Derio, 48160 Spain.
Erik UllianDepartment of Ophthalmology, School of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Marius WernigInstitute for Stem Cell Biology & Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.

Funding

Training Program in Basic NeuroscienceT32MH020016 · NIMH · STANFORD UNIVERSITY · PI Justin L Gardner, Merritt C Maduke · 1997 to 2026
$16.2M
Induced neuronal cells: A novel tool to study neuropsychiatric diseasesR01MH092931 · NIMH · STANFORD UNIVERSITY · PI Thomas C. Sudhof, Marius Wernig · 2010 to 2026
$9.7M
Probing Alzheimer synaptopathy in neurons derived from engineered human iPS cellsRF1AG048131 · NIA · STANFORD UNIVERSITY · PI SUDHOF, THOMAS C., WERNIG, MARIUS · 2014 to 2019
$5.4M
NIA NIH HHS RF1 AG048131NIMH NIH HHS R01 MH092931NIMH NIH HHS T32 MH020016
6 · The paper itself

Abstract

Microglia are the immune cells of the central nervous system and are thought to be key players in both physiological and disease conditions. Several microglial features are poorly conserved between mice and human, such as the function of the neurodegeneration-associated immune receptor Trem2. Induced pluripotent stem cell (iPSC)-derived microglia offer a powerful opportunity to generate and study human microglia. However, human iPSC-derived microglia often exhibit activated phenotypes

Identifiers

PMID40799568
PMCPMC12340862

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.