Evidence map›Paper›PMID 40799553›Full record

ArticlebioRxiv : the preprint server for biology2025

Identification of natural products and synthetic analogs which inhibit microsporidia spores and prevent infection.

Qingyuan Huang, Lauren E Brown, Guoqing Pan, Junhong Wei, John A Porco, Jie Chen, Aaron W Reinke

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Qingyuan HuangDepartment of Molecular Genetics, University of Toronto, Toronto, ON, Canada.
Lauren E BrownDepartment of Chemistry and Center for Molecular Discovery (BU-CMD), Boston University, Boston, MA, USA.
Guoqing PanState Key Laboratory of Resource Insects, Chongqing Key Laboratory of Microsporidia Infection and Control, Southwest University, Chongqing, China.
Junhong WeiState Key Laboratory of Resource Insects, Chongqing Key Laboratory of Microsporidia Infection and Control, Southwest University, Chongqing, China.
John A PorcoDepartment of Chemistry and Center for Molecular Discovery (BU-CMD), Boston University, Boston, MA, USA.
Jie ChenState Key Laboratory of Resource Insects, Chongqing Key Laboratory of Microsporidia Infection and Control, Southwest University, Chongqing, China.
Aaron W ReinkeDepartment of Molecular Genetics, University of Toronto, Toronto, ON, Canada.ORCID 0000-0001-7612-5342

Funding

BU-CMD Chemical Library Consortium: Fostering Collaborations between Chemists and Biologists for Translational DiscoveryU01TR002625 · NCATS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI PORCO, JOHN A. · 2020 to 2023
$2.7M
NCATS NIH HHS U01 TR002625
6 · The paper itself

Abstract

Microsporidiosis, a disease caused by microsporidia, affects many animals, with symptoms ranging from diarrhea to death, especially in immunocompromised individuals. Current treatments, such as albendazole and fumagillin, are limited in efficacy. To address this problem, we utilized

Identifiers

PMID40799553
PMCPMC12340860

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.