ArticleF1000Research2025
Effectiveness Of The Core Activation And Rehabilitation Exercises For Knee Osteoarthritis - Program (CARE -KOA
Article in F1000Research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Prevalence of Strength Deficits of Core and Hip Stabilizers in Knee Osteoarthritis: A Cross-Sectional Study.Musculoskeletal care · 2026Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Knee osteoarthritis (KOA) is a prevalent condition. Recent research highlights the role of kinetic chain and core muscle involvement in disease progression, yet evidence for structured core activation protocols such as CARE-KOA© remains limited.This study addresses this gap by evaluating the effectiveness of CARE-KOA©, which specifically targets proximal stability and biomechanical deficits in KOA, aiming to enhance pain, function, and core endurance beyond conventional approaches. Methods: This prospective single-group pre-post study assessed the effect of a Participants underwent a 4-week CARE-KOA© regimen (12 supervised sessions, each including a 10-minute warm-up and core-focused exercises). Pre- and post-intervention assessments included pain (Visual Analog Scale, VAS), patient-reported outcomes (Knee Injury and Osteoarthritis Outcome Score, KOOS), physical function tests (30-second sit-to-stand, 40-meter fast-paced walk, stair climb, timed up-and-go), and knee muscle strength and core endurance. Statistical analysis was performed using non-parametric tests in JAMOVI. Results: Significant improvements were observed in pain at rest (mean change: 1.13 cm, p = 0.0006, d = 1.07) and during activity (mean change: 2.46 cm, p = 0.000001, d = 1.76), patient-reported outcomes (KOOS Pain: p = 0.00003, d = -0.83; KOOS ADL: p = 0.0000009, d = -1.19), and core endurance (p = 0.027, d = 0.21). Physical function tests also improved (stair climb: p = 0.031, d = 0.34; timed up-and-go: p = 0.006, d = 0.13). Muscle strength gains were significant in flexors of the unaffected knee and extensors of the affected knee (p < 0.05), while other muscle groups showed no significant change. Conclusion: The CARE-KOA© program led to clinically meaningful improvements in pain, function, and core endurance, highlighting the value of core activation strategies in KOA management. Future research with larger samples and longer follow-up is warranted to confirm these benefits and optimize exercise protocols. Study Trial Registration: CTRI/2023/07/05480 on 05/07/2024 https://ctri.nic.in/Clinicaltrials/regtrial.php?modid=1&compid=19&EncHid=69416.70327
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