Evidence map›Paper›PMID 40799449›Full record

ArticleTranslational lung cancer research2025

A case report and literature review of a pathologic complete response to alectinib in

Mélanie Janson, Hubert Curcio, Jean-Philippe Le Rochais, Gaëtane Planchard, Pierre Demontrond, Radj Gervais

Abstract readCase Reports
In one paragraph

Article in Translational lung cancer research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mélanie JansonFrançois BACLESSE, Comprehensive Cancer Center, Caen, France.ORCID https://orcid.org/0009-0006-4592-4620
Hubert CurcioFrançois BACLESSE, Comprehensive Cancer Center, Caen, France.
Jean-Philippe Le RochaisDepartment of Cardiovascular and Thoracic Surgery, University Hospital of Caen, Caen, France.
Gaëtane PlanchardDepartment of Anatomical and Cytological Pathology, University Hospital of Caen, Caen, France.
Pierre DemontrondFrançois BACLESSE, Comprehensive Cancer Center, Caen, France.
Radj GervaisFrançois BACLESSE, Comprehensive Cancer Center, Caen, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Stage IV non-small cell lung cancer is not a curative stage. However, a novel approach to local treatment of the primary tumor may improve progression-free survival. The choice between radiotherapy or surgery, as well as the optimal timing for these treatments remains to be determined. We report here the first case, to our knowledge, of a multi-metastatic patient treated with consolidative surgery after neoadjuvant alectinib, resulting in a complete pathological response. Case Description: The patient was, as is typically observed in populations with oncogenic alterations such as anaplastic lymphoma kinase ( Conclusions: This case suggests that local treatment, even in patients with stage IV disease, performed at the time of the best response to systemic therapy, may offer an improvement in progression free survival and perhaps a glimpse of a cure.

Indexed as

alectinibCase reportcomplete responsenon-small cell lung cancer (NSCLC)stage IV

Identifiers

PMID40799449
PMCPMC12337049

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.