Evidence map›Paper›PMID 40799360›Full record

ArticleJHLT open2025

Evaluation of potential mechanisms for skeletal muscle mass recovery early after left ventricular assist device implantation.

Didjana Celkupa, Benjamin A Sweigart, Joronia Chery, Alex Coston, Laura Telfer, Matthew Lawrence, Michael S Kiernan, Gregory S Couper, Masashi Kawabori, Nathan LeBrasseur and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JHLT open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Didjana CelkupaCardioVascular Center, Tufts Medical Center, Boston, MA.
Benjamin A SweigartBiostatistics, Epidemiology, and Research Design (BERD) Center, Tufts Clinical and Translational Science Institute, Tufts Medical Center, Boston, MA.
Joronia CheryTufts University School of Medicine, Boston, MA.
Alex CostonDepartment of Family and Community Medicine, San Francisco General Hospital, University of California San Francisco, San Francisco, CA.
Laura TelferPenn State College of Medicine, State College, PA.
Matthew LawrenceCardioVascular Center, Tufts Medical Center, Boston, MA.
Michael S KiernanCardioVascular Center, Tufts Medical Center, Boston, MA.
Gregory S CouperCardioVascular Center, Tufts Medical Center, Boston, MA.
Masashi KawaboriCardioVascular Center, Tufts Medical Center, Boston, MA.
Nathan LeBrasseurDepartment of Physical Medicine and Rehabilitation, and Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN.
Edward SaltzmanFriedman School of Nutrition Science and Policy at Tufts University, Boston, MA.
Amanda R VestKaufman Center for Heart Failure Treatment and Recovery, Department of Cardiovascular Medicine, Heart, Vascular and Thoracic Institute, Cleveland Clinic, Cleveland, OH.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: We observed significant gains in appendicular lean mass (ALM) over the first 6 months of left ventricular assist device (LVAD) support for patients with heart failure with reduced ejection fraction (HFrEF). We sought to determine whether improved HF neurohumoral stability, inflammation, physical activity, or nutrition, are most closely related to this muscle mass recovery. Methods: We prospectively recruited 30 adults with HFrEF ±21 days from LVAD implantation. Dual X-ray absorptiometry (DXA) measured ALM at baseline and at 3- and 6-months post-LVAD implantation ( Results: At baseline, participants (87% male, mean age 56 ± 12 years) showed a significant negative association between ALM and log N-terminal-pro B natriuretic peptide (NT-proBNP) ( Conclusions: The recovery in ALM over the first 6 months of LVAD support was most closely associated with improved HF neurohumoral stability and inflammation, rather than activity or nutritional changes.

Indexed as

Heart failureLean massLeft ventricular assist deviceMetabolismNutritionPhysical activitySkeletal muscle

Identifiers

PMID40799360
PMCPMC12340567

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.