Evidence map›Paper›PMID 40799345›Full record

ArticlePNAS nexus2025

Mechanism of the dual action self-potentiating antitubercular drug morphazinamide.

Lev Ostrer, Taylor A Crooks, Michael D Howe, Sang Vo, Ziyi Jia, Pooja Hegde, Nathan Schacht, Courtney C Aldrich, Anthony D Baughn

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PNAS nexus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. TargetingACS omega · 2026
    Article
  2. mBio · 2026
    Article
  3. bioRxiv : the preprint server for biology · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Lev OstrerDepartment of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
Taylor A CrooksDepartment of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.ORCID https://orcid.org/0000-0001-7608-1992
Michael D HoweDepartment of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
Sang VoDepartment of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.ORCID https://orcid.org/0000-0002-2005-2372
Ziyi JiaDepartment of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.ORCID https://orcid.org/0000-0001-8279-5561
Pooja HegdeDepartment of Medicinal Chemistry, College of Pharmacy, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
Nathan SchachtDepartment of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.ORCID https://orcid.org/0009-0007-7081-7648
Courtney C AldrichDepartment of Medicinal Chemistry, College of Pharmacy, University of Minnesota Medical School, Minneapolis, MN 55455, USA.
Anthony D BaughnDepartment of Microbiology and Immunology, University of Minnesota Medical School, Minneapolis, MN 55455, USA.ORCID https://orcid.org/0000-0003-1188-4238

Funding

TRAINING-PULMONARY CELL &MOLECULAR BIOLOGY &PHYSIOLOGYT32HL007741 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI DUDLEY, R. ADAMS, INGBAR, DAVID H · 1994 to 2023
$13.9M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM008244 · NIGMS · UNIVERSITY OF MINNESOTA TWIN CITIES · PI SHIMIZU, YOJI · 1988 to 2024
$13.6M
The impact of pyrazinamide on metabolism in Mycobacterium tuberculosis.R01AI123146 · NIAID · UNIVERSITY OF MINNESOTA · PI BAUGHN, ANTHONY D · 2016 to 2025
$4.3M
NHLBI NIH HHS T32 HL007741NIAID NIH HHS R01 AI123146NIGMS NIH HHS T32 GM008244
6 · The paper itself

Abstract

Pyrazinamide (PZA) is a cornerstone of first-line antitubercular drug therapy and is unique in its ability to kill nongrowing populations of

Indexed as

coenzyme Adrug discoverypyrazinamidethiol stresstuberculosis

Identifiers

PMID40799345
PMCPMC12342587

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.