Evidence map›Paper›PMID 40799281›Full record

ArticleBrain communications2025

Brain corticospinal tract abnormalities in aquaporin-4 seropositive neuromyelitis optica spectrum disorder with longitudinally extensive transverse myelitis.

Chengyi Zhang, Yajun Yao, Jiali Sun, Yun Xu, Huabing Wang, Zhi-Zheng Zhuo, Yunyun Duan, Xinghu Zhang, Yaou Liu, Wencai Ding and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Chengyi ZhangDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.
Yajun YaoDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.
Jiali SunDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.
Yun XuDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.
Huabing WangDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.
Zhi-Zheng ZhuoDepartment of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.
Yunyun DuanDepartment of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.
Xinghu ZhangDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.
Yaou LiuDepartment of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.
Wencai DingDepartment of Neurology, The Second Affiliated Hospital of Wannan Medical College, Wuhu 214002, China.
De-Cai TianDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China.ORCID https://orcid.org/0000-0002-5153-2491

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Widespread white matter changes, including those in the corticospinal tract (CST), have been observed in patients with neuromyelitis optica spectrum disorder (NMOSD). However, whether these alterations originate within the brain or result from spinal cord damage remains unclear. To investigate the CST alteration in AQP4-IgG positive NMOSD with longitudinally extensive transverse myelitis (LETM), and evaluate its relevance to LETM via fixel-based analysis. AQP4+ LETM patients and healthy controls were from ongoing clinical and imaging patterns of neuroinflammation diseases in China cohort between December 2018 and September 2023. Fibre density, fibre cross-section, and the combined measure of fibre density and fibre cross-section were calculated in CST. Serum neurofilament light chain and glial fibrillary acidic protein levels were determined using single-molecule arrays. Multivariate linear model was used to assess associations in AQP4+ LETM between fixel parameters and clinical variables. 44 AQP4+ LETM and 48 healthy controls were included in the study. Among AQP4+ LETM, CST exhibited a decreased mean fibre cross-section (

Indexed as

aquaporin-4corticospinal tractfixel-Based analysislongitudinally extensive transverse myelitisneuromyelitis optica spectrum disorder

Identifiers

PMID40799281
PMCPMC12342178

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.