Evidence map›Paper›PMID 40799279›Full record

ArticleBrain communications2025

Neurodevelopmental screening in children with early-onset spinal muscular atrophy in the treatment era: a strengths-based cohort study.

Lakshmi Balaji, Didu Kariyawasam, Karen Herbert, Hugo A Sampaio, Anita Cairns, Brittany C McGill, Lauren Kelada, Susan Woolfenden, Nancy Briggs, Michelle A Farrar

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lakshmi BalajiDepartment of Neurology, Sydney Children's Hospital Randwick, Sydney, NSW 2031, Australia.ORCID https://orcid.org/0000-0001-9286-900X
Didu KariyawasamDepartment of Neurology, Sydney Children's Hospital Randwick, Sydney, NSW 2031, Australia.
Karen HerbertDepartment of Neurology, Sydney Children's Hospital Randwick, Sydney, NSW 2031, Australia.
Hugo A SampaioDepartment of Neurology, Sydney Children's Hospital Randwick, Sydney, NSW 2031, Australia.
Anita CairnsQueensland Children's Hospital, Brisbane, QLD 4101, Australia.
Brittany C McGillDiscipline of Paediatrics and Child Health, School of Clinical Medicine, UNSW Medicine and Health, University of New South Wales, Sydney, NSW 2031, Australia.
Lauren KeladaDiscipline of Paediatrics and Child Health, School of Clinical Medicine, UNSW Medicine and Health, University of New South Wales, Sydney, NSW 2031, Australia.ORCID https://orcid.org/0000-0001-9428-8807
Susan WoolfendenCentral Clinical School, Sydney Medical School, the Faculty of Medicine and Health, University of Sydney, Sydney 2006, Australia.
Nancy BriggsStats Central, Mark Wainwright Analytical Centre, University of New South Wales, Sydney, NSW 2031, Australia.
Michelle A FarrarDepartment of Neurology, Sydney Children's Hospital Randwick, Sydney, NSW 2031, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

With transformative advances in diagnostic and therapeutic approaches in spinal muscular atrophy, the long-term neurodevelopmental outcomes of children with, or predicted to have, spinal muscular atrophy type 1 are essential to evaluate. In this single-centre cross-sectional study, development in children with/at-risk of spinal muscular atrophy type 1, aged 1-66 months, was assessed using parent-reported Ages and Stages Questionnaires® (ASQ-3™). Risk of autism spectrum disorder (ASD), parental distress, sociodemographic and clinical characteristics were also evaluated. Associations between exploratory variables and developmental risk were analysed within a bioecological model of health. Adaptive least absolute shrinkage and selection operator (LASSO) was used to identify variables most predictive of developmental acquisition. Thirty-seven children with spinal muscular atrophy participated (response rate: 90.2%, girls: 54.0%). Clinical characteristics varied with modality of diagnosis, survival motor neuron 2 (

Indexed as

ages and stages questionnaireautism spectrum disorderneurodevelopmentSMN-associated neurodevelopmental disordersspinal muscular atrophy

Identifiers

PMID40799279
PMCPMC12341873

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.