ArticleFrontiers in oncology2025
SHCBP1 drives tumor progression in triple-negative breast cancer.
Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Backgrounds: Triple-negative breast cancer (TNBC) represents the most aggressive breast cancer subtype. The limited treatment options underscore the urgent need to explore novel molecular targets to combat TNBC progression. This study investigates the oncogenic functions of SHCBP1 in TNBC. Materials and methods: Bulk RNA-seq and single-cell sequencing (scRNA-seq) data for TNBC samples were acquired from the Cancer Genome Atlas (TCGA) dataset and GSE161529, respectively. SHCBP1 expression at the mRNA and protein levels was compared between TNBC and normal breast tissues. The prognostic significance of SHCBP1 in TNBC was assessed using Kaplan-Meier analysis. The potential biological functions of SHCBP1 were explored through gene ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and gene set enrichment analysis (GSEA). Immunofluorescence was utilized to determine the subcellular localization of SHCBP1 during cell division. Quantitative PCR (qPCR) and western blotting were employed to measure SHCBP1 expression in breast cancer cell lines. Subsequently, the impact of SHCBP1 on TNBC cell proliferation and migration was evaluated Results: SHCBP1 is markedly upregulated in TNBC tissues, and its overexpression is associated with poorer survival outcomes. Functional enrichment analysis reveals that SHCBP1-related genes are significantly enriched in pathways involved in cell-cycle regulation and DNA damage response. Conclusions: This study elucidates the critical role of SHCBP1 in TNBC progression, highlighting its potential as a therapeutic target. These findings provide a foundation for further exploration of SHCBP1 in TNBC treatment strategies.
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