ArticleContemporary clinical dentistry
Determination of Salivary CD44 as a Noninvasive Diagnostic Biomarker to Predict Malignant Transformation of Oral Submucous Fibrosis.
Article in Contemporary clinical dentistry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Role of Stem Cells and Stem Cell Markers in Oral Potentially Malignant Disorders and Malignant Transformation: A Systematic Review.Stem cells international · 2026Review
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5 authors.
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Abstract
Background: In the case of oral potentially malignant disorders such as oral submucous fibrosis (OSMF), leukoplakia and in oral cancer, cancer stem cells are reported to be present. Cluster of differentiation 44 (CD44) is a stem cell involved in various cellular regulation pathways and detected in proficient amounts as molecular biomarkers in saliva that are cleaved and released but surprisingly no evidence to support its diagnostic value in OSMF. Aim: The aim of the study was to determine the CD44 expression in the salivary sample of OSMF patients and to evaluate its effectiveness as a noninvasive diagnostic marker. Materials and Methods: Group 1 included 30 controls and Group 2 included 30 OSMF cases. Salivary samples were collected and subjected to enzyme-linked immunosorbent assay for determining the CD44 values. Grading of OSMF was done based on clinical examination and histopathological investigation. The data obtained were subjected to statistical analysis (SPSS Version 24) Chi-square test, independent Results: In Group 2, there was male predominance with 86.7% ( Conclusion: Our study was the first of its kind to assess the expression of CD44 in OSMF patients. Results infer that CD44 may decrease with the progression of normal mucosa to OSMF and with different grades, however, future studies are required with larger sample size to determine CD44 as molecular biomarker.
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