Evidence map›Paper›PMID 40799205›Full record

ArticleMolecular therapy. Methods & clinical development2025

Development of VNX-101, an adeno-associated virus with less immunogenicity and efficient long-term expression of a CD19 T cell engager.

Mark A Currier, Allen Reha, Brian Hutzen, Pin-Yi Wang, Chun-Yu Chen, Andrea M Glaspell, Siddhi Nath Paudel, Akila S Venkataramany, Debashree Das, Danielle Hanlon and 8 more

Abstract read
In one paragraph

Article in Molecular therapy. Methods & clinical development, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Mark A CurrierCenter for Childhood Cancer Research, Abigail Wexner Research Institute at Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH 43205, USA.
Allen RehaVironexis Biotherapeutics, Inc., 9310 Athena Circle, La Jolla, CA 92037, USA.
Brian HutzenCenter for Childhood Cancer Research, Abigail Wexner Research Institute at Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH 43205, USA.
Pin-Yi WangCenter for Childhood Cancer Research, Abigail Wexner Research Institute at Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH 43205, USA.
Chun-Yu ChenCenter for Childhood Cancer Research, Abigail Wexner Research Institute at Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH 43205, USA.
Andrea M GlaspellCenter for Childhood Cancer Research, Abigail Wexner Research Institute at Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH 43205, USA.
Siddhi Nath PaudelCenter for Childhood Cancer Research, Abigail Wexner Research Institute at Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH 43205, USA.
Akila S VenkataramanyCenter for Childhood Cancer Research, Abigail Wexner Research Institute at Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH 43205, USA.
Debashree DasVironexis Biotherapeutics, Inc., 9310 Athena Circle, La Jolla, CA 92037, USA.
Danielle HanlonVironexis Biotherapeutics, Inc., 9310 Athena Circle, La Jolla, CA 92037, USA.
Allan KasparVironexis Biotherapeutics, Inc., 9310 Athena Circle, La Jolla, CA 92037, USA.
Samit VarmaVironexis Biotherapeutics, Inc., 9310 Athena Circle, La Jolla, CA 92037, USA.
Brian KasparVironexis Biotherapeutics, Inc., 9310 Athena Circle, La Jolla, CA 92037, USA.
Pablo MoralesThe Mannheimer Foundation, Inc., 20255 SW 360 Street, Homestead, FL 33034, USA.
Peter RalphMarin Biologic Laboratories, Inc, 378 Bel Marin Keys Boulevard, Novato, CA 94949, USA.
Tonny JohnsonMarin Biologic Laboratories, Inc, 378 Bel Marin Keys Boulevard, Novato, CA 94949, USA.
Tania L WeissMarin Biologic Laboratories, Inc, 378 Bel Marin Keys Boulevard, Novato, CA 94949, USA.
Timothy P CripeCenter for Childhood Cancer Research, Abigail Wexner Research Institute at Nationwide Children's Hospital, 700 Children's Drive, Columbus, OH 43205, USA.

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Daniel G. Stover · 1985 to 2026
$132.3M
Project 4:Targeting M2-like Macrophages and MDSC with Myelolytic-VirotherapyU54CA232561 · NCI · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI CASSADY, KEVIN A, CRIPE, TIMOTHY P · 2019 to 2023
$12.1M
A New Paradigm to Prevent and Treat MicrometastasesR01CA278995 · NCI · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI TIMOTHY P CRIPE · 2024 to 2026
$1.5M
NCI NIH HHS P30 CA016058NCI NIH HHS R01 CA278995NCI NIH HHS U54 CA232561
6 · The paper itself

Abstract

We previously described the use of recombinant adeno-associated virus (AAV) gene therapy to achieve off-the-shelf, long-term

Indexed as

adeno-associated virus, AAVB cell leukemia/lymphomabiodistributionbispecific T cell engagerCD19toxicology

Identifiers

PMID40799205
PMCPMC12341704

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.