Evidence map›Paper›PMID 40799176›Full record

ArticleAllergy2026

Reduced Type-I Interferon by Plasmacytoid Dendritic Cells and Asthma in School-Aged Children.

Isabelle Coenen, Anya C Jones, Alice A White, Mari Takashima, Wen Ray Lee, Matthew D Wong, Dwan Vilcins, Ulrich Kadolsky, Ali Sadiq Cheema, Alka Saxena and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Allergy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Isabelle CoenenWal-Yan Respiratory Research Centre, The Kids Research Institute Australia, University of Western Australia, Perth, Western Australia, Australia.
Anya C JonesWal-Yan Respiratory Research Centre, The Kids Research Institute Australia, University of Western Australia, Perth, Western Australia, Australia.
Alice A WhiteThe Kids Research Institute Australia, University of Western Australia, Perth, Western Australia, Australia.
Mari TakashimaChild Health Research Centre, The University of Queensland, South Brisbane, Queensland, Australia.
Wen Ray LeeChild Health Research Centre, The University of Queensland, South Brisbane, Queensland, Australia.
Matthew D WongChild Health Research Centre, The University of Queensland, South Brisbane, Queensland, Australia.
Dwan VilcinsChild Health Research Centre, The University of Queensland, South Brisbane, Queensland, Australia.
Ulrich KadolskyGenomics WA, Perth, Western Australia, Australia.
Ali Sadiq CheemaGenomics WA, Perth, Western Australia, Australia.
Alka SaxenaGenomics WA, Perth, Western Australia, Australia.
Anthony BoscoINSiGENe Pty Ltd, Perth, Western Australia, Australia.
Keith GrimwoodSchool of Medicine and Dentistry, Griffith University, Gold Coast, Queensland, Australia.
Peter D SlyChild Health Research Centre, The University of Queensland, South Brisbane, Queensland, Australia.
Deborah H StricklandWal-Yan Respiratory Research Centre, The Kids Research Institute Australia, University of Western Australia, Perth, Western Australia, Australia.
Jonatan LefflerWal-Yan Respiratory Research Centre, The Kids Research Institute Australia, University of Western Australia, Perth, Western Australia, Australia.

Funding

Stan Perron Charitable FoundationWal-yan Respiratory Research Centre
6 · The paper itself

Abstract

backgroundAllergic sensitization and reduced ability to respond to viral infections may contribute to virus-induced wheeze and asthma development in young children. Plasmacytoid dendritic cells (pDC) are rare immune cells that produce type I interferons (IFN-I) and play a key role in orchestrating immune responses against viruses.

objectiveTo further evaluate the function of pDC in children with asthma.

methodsThis study was based on a subset of 71 children from the Early Life Lung Function (ELLF) cohort at the age of 7 years. As part of the ELLF study, participants were characterized for atopic sensitization, viral infection history, and lung function testing. pDC responses to a TLR7/8 agonist were assessed in the presence or absence of anti-IgE using an in vitro assay. Responses were evaluated utilizing flow cytometry, multiplexed cytokine assays, and transcriptional analysis of isolated pDC.

resultspDC responses varied considerably across individuals, and those who responded with IFN-I following stimulation showed a lower proportion of asthma compared to those who responded with TNF-only. A TNF-only response was associated with increased atopy and reduced upregulation of IFN-associated genes. Anti-IgE stimulation reduced pDC activation, and the reduction was associated with baseline expression of the IgE receptor (FcεR1). A reduction in a gene module centralized around genes such as TPM2, LILRA4, and CLEC4C was also observed.

conclusionTogether, these findings suggest that pDC responses are variable, associated with asthma, and appear influenced by environmental stimuli. This response thus appears to be an important aspect of asthma pathology in children.

Indexed as

AsthmaDendritic CellsInterferon Type IChildCytokinesFemaleHumansMaleCytokinesInterferon Type Ichildhood asthmaIgEinterferon responseplasmacytoid dendritic cells

Identifiers

PMID40799176
PMCPMC12773650

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.