ArticleJournal of cosmetic dermatology2025
Synchronized RF and HIFES Technology for Clinically Significant Wrinkle Reduction: A Multicenter 3D Evaluation.
Article in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Synchronized RF and HIFES Technology for Clinically Significant Wrinkle Reduction: A Multicenter 3D Evaluation.Journal of cosmetic dermatology · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe pursuit of youthful skin reflects its association with health and well-being. Energy-based procedures are increasingly favored for their noninvasive nature and ability to target signs of aging at the tissue level through controlled thermal or mechanical stimulation.
aimsThis study evaluated the HIFES combined with synchronized radiofrequency (RF) as a noninvasive wrinkle treatment.
methodsThirty-three patients underwent four treatments using HIFES and synchronized RF. Follow-up visits occurred at 1 and 3 months post-treatment. Wrinkle severity was assessed using 3D photographs and expressed as a percentage change, while 2D photographs were evaluated using the Global Aesthetic Improvement Scale (GAIS) and the Fitzpatrick Wrinkle and Elastosis Scale (FWES). Patient-reported outcomes included a 5-point Likert scale satisfaction survey and a comfort questionnaire.
resultsSignificant wrinkle reduction was observed. 3D analysis showed wrinkle improvements of 20.13% ± 0.33% post-treatment, 23.15% ± 0.32% at 1 month, and 35.36% ± 3.34% at 3 months. At 3 months, 88% of participants improved by at least one GAIS point. FWES score declined from 5.6 to 3.8, reflecting a shift from wrinkle severity class II to I. High satisfaction and comfort were reported.
conclusionsHIFES combined with synchronized RF effectively reduces wrinkle severity, as evidenced by objective measurements and patient feedback. This noninvasive treatment offers a safe and well-tolerated option for improving skin appearance and quality.
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Registered trials
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