ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025
Astrovascular decoupling in awake 5×FAD mice is associated with reduced astrocytic calcium.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Astrocyte-blood-brain barrier crosstalk in cerebral small vessel disease: linking barrier dysfunction to neurovascular failure.Frontiers in neurology · 2026Review
- Presence of Astrocytic S1R/5-HT1A Heterocomplex in the mPFC: A Putative Link to S1R Activation Mediated Faster Antidepressant-Like Effects.Molecular neurobiology · 2025Article
- Astrovascular decoupling in awake 5×FAD mice is associated with reduced astrocytic calcium.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
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Authors and funding
11 authors.
Funding
Abstract
introductionEvidence points to dysregulated Ca
methodsAstrocytic Ca
resultsAlong with increases in amyloid beta (Aβ) accumulation, we found significant reductions in measures of astrocyte functional connectivity, pairwise correlations, and network synchronicity in older 5×FAD mice, with greater decreases in females. Results align with altered gait and reduced astrovascular coupling. DISCUSSION: The results provided here are novel and demonstrate that age and sex are major risk factors for AD; however, central astrovascular dysregulations appear to exist in response to reduced, rather than elevated astrocyte Ca HIGHLIGHTS: Gait analyses reveal older 5×FAD animals display shorter stride length while ambulating. While resting astrocytic calcium activity is increased with age, sex, and genotypes, these results do not explain changes in astrovascular coupling. Only small changes in astrocyte calcium transients and vessel morphology are seen, while the astrocyte-to-vessel correlations (astrovascular coupling) are significantly reduced. Astrocyte network analysis reveals significant reductions in measures of astrocytic communication and activity which are associated with reduced functional vasoreactivity in awake ambulating animals.
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