Evidence map›Paper›PMID 40799086›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Shear Stress Targeted Delivery of Nitroglycerin to Brain Collaterals Improves Ischaemic Stroke Outcome.

Magdalena Litman, Sara Azarpeykan, Rebecca J Hood, Kristy Martin, Debbie Pepperall, Daniel Omileke, Fern Williams, Oktay Uzun, Deen Bhatta, Yuen K Yong and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Improving physiological monitoring and reporting standards in preclinical stroke research.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Magdalena LitmanSchool of Biomedical Science and Pharmacy, The University of Newcastle, Newcastle, 2308, Australia.
Sara AzarpeykanSchool of Biomedical Science and Pharmacy, The University of Newcastle, Newcastle, 2308, Australia.
Rebecca J HoodSchool of Biomedical Science and Pharmacy, The University of Newcastle, Newcastle, 2308, Australia.
Kristy MartinSchool of Biomedical Science and Pharmacy, The University of Newcastle, Newcastle, 2308, Australia.
Debbie PepperallSchool of Biomedical Science and Pharmacy, The University of Newcastle, Newcastle, 2308, Australia.
Daniel OmilekeSchool of Biomedical Science and Pharmacy, The University of Newcastle, Newcastle, 2308, Australia.
Fern WilliamsSchool of Biomedical Science and Pharmacy, The University of Newcastle, Newcastle, 2308, Australia.
Oktay UzunWyss Institute of Biologically Inspired Engineering, Harvard University, Boston, MA, 02215, USA.
Deen BhattaWyss Institute of Biologically Inspired Engineering, Harvard University, Boston, MA, 02215, USA.
Yuen K YongSchool of Engineering, University of Newcastle, Callaghan, NSW, 2308, Australia.
Alex ChanSchool of Engineering, University of Newcastle, Callaghan, NSW, 2308, Australia.
Nicholas HoughSchool of Engineering, University of Newcastle, Callaghan, NSW, 2308, Australia.
Sarah JohnsonSchool of Engineering, University of Newcastle, Callaghan, NSW, 2308, Australia.
Pablo Garcia BermejoDepartment of Neurology, John Hunter Hospital, Hunter New England Local Health District, Newcastle, 2305, Australia.
Ferdinand MiteffDepartment of Neurology, John Hunter Hospital, Hunter New England Local Health District, Newcastle, 2305, Australia.
Carlos Garcia EsperonDepartment of Neurology, John Hunter Hospital, Hunter New England Local Health District, Newcastle, 2305, Australia.
Yvonne CouchAcute Stroke Programme, Radcliffe Department of Medicine, University of Oxford, Oxford, OX39DU, UK.
Alastair M BuchanAcute Stroke Programme, Radcliffe Department of Medicine, University of Oxford, Oxford, OX39DU, UK.
Neil J SprattSchool of Biomedical Science and Pharmacy, The University of Newcastle, Newcastle, 2308, Australia.
Netanel KorinWyss Institute of Biologically Inspired Engineering, Harvard University, Boston, MA, 02215, USA.
Donald E IngberWyss Institute of Biologically Inspired Engineering, Harvard University, Boston, MA, 02215, USA.
Daniel J BeardSchool of Biomedical Science and Pharmacy, The University of Newcastle, Newcastle, 2308, Australia.ORCID https://orcid.org/0000-0002-3720-7588

Funding

Hansjörg Wyss Institute for Biologically Inspired Engineering, Harvard UniversityNational Health and Medical Research Council APP1182153Oxford University Medical Sciences Internal Fund
6 · The paper itself

Abstract

In patients with ischaemic stroke, retrograde perfusion of the penumbra by leptomeningeal collateral vessels (LMCs) strongly predicts clinical outcome, suggesting that enhancing LMC flow can offer a novel therapeutic approach. Using in vivo measurements and computational modelling it is shown that LMCs experience elevated fluid shear stress that is significantly higher than that in other blood vessels during ischaemic stroke in rats and humans. We exploit this to selectively enhance flow in LMCs using shear-activated nanoparticle aggregates carrying the vasodilator nitroglycerin (NG-NPAs) that specifically release drug in regions of vessels with high wall shear stress (≥100 dyne cm

Indexed as

BrainCollateral CirculationIschemic StrokeNitroglycerinAnimalsCerebrovascular CirculationDisease Models, AnimalDrug Delivery SystemsHumansMaleRatsRats, Sprague-DawleyStress, MechanicalVasodilator AgentsNitroglycerinVasodilator Agentscollateralscollateral therapeuticsischaemic strokenanotherapeuticsshear stress

Identifiers

PMID40799086
PMCPMC12561270

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.