Evidence map›Paper›PMID 40798962›Full record

ReviewRecent patents on anti-cancer drug discovery2026

Roles of TEAD Transcription Factors and their Coactivators in the Progression and Metastasis of Cancers.

Li Xiao, Ning Zhang, Peng-Quan Li, Hai-Qing Chu, Dong Zhao, Wei Qin, Shou-Ping Gong, Hui-Ling Cao

Abstract readReview
PubMed Publisher
In one paragraph

Review in Recent patents on anti-cancer drug discovery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Li XiaoXi'an Key Laboratory of Basic and Translation of Cardiovascular Metabolic Disease, Xi'an Key Laboratory of Autoimmune Rheumatic Disease, College of Pharmacy, Xi'an Medical University, Xi'an 710021, Shaanxi, China.
Ning ZhangXi'an Key Laboratory of Basic and Translation of Cardiovascular Metabolic Disease, Xi'an Key Laboratory of Autoimmune Rheumatic Disease, College of Pharmacy, Xi'an Medical University, Xi'an 710021, Shaanxi, China.
Peng-Quan LiXi'an Key Laboratory of Basic and Translation of Cardiovascular Metabolic Disease, Xi'an Key Laboratory of Autoimmune Rheumatic Disease, College of Pharmacy, Xi'an Medical University, Xi'an 710021, Shaanxi, China.
Hai-Qing ChuXi'an Key Laboratory of Basic and Translation of Cardiovascular Metabolic Disease, Xi'an Key Laboratory of Autoimmune Rheumatic Disease, College of Pharmacy, Xi'an Medical University, Xi'an 710021, Shaanxi, China.
Dong ZhaoXi'an Key Laboratory of Basic and Translation of Cardiovascular Metabolic Disease, Xi'an Key Laboratory of Autoimmune Rheumatic Disease, College of Pharmacy, Xi'an Medical University, Xi'an 710021, Shaanxi, China.
Wei QinXi'an Key Laboratory of Basic and Translation of Cardiovascular Metabolic Disease, Xi'an Key Laboratory of Autoimmune Rheumatic Disease, College of Pharmacy, Xi'an Medical University, Xi'an 710021, Shaanxi, China.
Shou-Ping GongXi'an Key Laboratory of Basic and Translation of Cardiovascular Metabolic Disease, Xi'an Key Laboratory of Autoimmune Rheumatic Disease, College of Pharmacy, Xi'an Medical University, Xi'an 710021, Shaanxi, China.
Hui-Ling CaoXi'an Key Laboratory of Basic and Translation of Cardiovascular Metabolic Disease, Xi'an Key Laboratory of Autoimmune Rheumatic Disease, College of Pharmacy, Xi'an Medical University, Xi'an 710021, Shaanxi, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The transcriptional enhanced associate domain (TEAD) family of transcription factors and their coactivators play pivotal roles in the Hippo-YAP/TAZ pathway, a critical regulatory axis involved in oncogenesis and tumor progression. To investigate the functional interactions of TEAD transcription factors, we performed comprehensive analyses of gene regulatory networks associated with TEADs. TEADs regulate oncogenesis and tumor progression through interactions with upstream oncogenic signaling pathways and the regulation of downstream target genes. As pivotal transcription factors, TEADs critically regulate multiple oncogenic processes, including epithelial-mesenchymal transition (EMT), proliferation, apoptosis, migration, invasion, metastasis, and aerobic glycolysis in cancer cells. TEADs are regulated by numerous non-coding RNAs [ncRNAs] through the Hippo, AKT, and TGF-β signaling pathways in cancers. These insights establish a strong molecular rationale for developing TEAD-targeted therapeutic strategies in cancer treatment.

Indexed as

DNA-Binding ProteinsNeoplasmsTranscription FactorsAnimalsDisease ProgressionEpithelial-Mesenchymal TransitionGene Expression Regulation, NeoplasticHumansNeoplasm MetastasisSignal TransductionTEA Domain Transcription FactorsDNA-Binding ProteinsTEA Domain Transcription FactorsTranscription Factorscancer therapyhippo pathwaymolecular markersTEADtranscription factors

Identifiers

PMID40798962

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.