Trial reportJournal of pediatric gastroenterology and nutrition2025
Liver function tests among children with moderate acute malnutrition: A secondary analysis of a randomized trial from Burkina Faso.
Trial report in Journal of pediatric gastroenterology and nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Liver function tests among children with moderate acute malnutrition: A secondary analysis of a randomized trial from Burkina Faso.Journal of pediatric gastroenterology and nutrition · 2025Trial
- Biochemical and Inflammatory Profiles in Paediatric Obesity, Undernutrition and Normal Weight: A Single-Centre Retrospective Cohort Study.Children (Basel, Switzerland) · 2026Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
objectivesHepatic steatosis has been described in children with severe acute malnutrition, but the degree of liver damage in children with moderate acute malnutrition (MAM) is unknown. This study aimed to investigate the development of malnutrition-associated liver damage by describing liver function tests among children with MAM.
methodsThis study was a randomized 2 × 2 × 3 factorial trial, Treatfood, conducted in Burkina Faso. Children (6-23 months) with MAM received either a lipid-based nutrient supplement or a corn-soy blend, containing either dehulled soy or soy isolate and different quantities of dried skim milk. Malaria rapid diagnostic tests and liver function tests were performed at inclusion and after 3 months of supplementation and compared to Danish reference intervals. Associations were analyzed with linear regressions or tobit regressions, and odds ratios were calculated with logistic regressions, all age- and sex-adjusted.
resultsIn total, 1405 children had one or more liver function tests measured at baseline. The median age was 11.4 months [interquartile range: 8.2-16.1]. Few children had elevated concentrations of liver function tests at baseline. Concentrations of total bilirubin were 19% (95% confidence interval: 2-40) greater among children with length-for-age Z-scores <-3 compared with children with Z-scores ≥-2. The concentrations of total bilirubin and alkaline phosphatase were negatively associated with age. Minor changes in the serum concentrations of liver function tests were observed after intervention.
conclusionsLiver function tests were largely within the normal range, whereby no signs of manifest liver damage were found. Children with stunted growth had higher bilirubin, which might indicate subclinical liver damage. CLINICAL
trial registrationISRCTN number: ISRCTN42569496.
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