ArticleJPEN. Journal of parenteral and enteral nutrition2025
Association between nutrition risk and oral mucosal membrane pressure injury in critically ill adults requiring endotracheal tube placement: A prospective cohort study.
Article in JPEN. Journal of parenteral and enteral nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Incidence and risk factors of oral mucosal pressure injury in patients with oral tracheal intubation: systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
- Article
- Association between nutrition risk and oral mucosal membrane pressure injury in critically ill adults requiring endotracheal tube placement: A prospective cohort study.JPEN. Journal of parenteral and enteral nutrition · 2025Article
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Authors and funding
9 authors.
Funding
Abstract
backgroundOral mucosal membrane pressure injuries are common yet underrecognized complications in critically ill patients with endotracheal tubes. This study investigated the association between nutrition risk and oral mucosal membrane pressure injuries.
methodsThis multicenter prospective cohort study enrolled 1533 intensive care unit patients with endotracheal tubes between April and December 2023. The primary model examined the association between nutrition risk and oral mucosal membrane pressure injuries. Additional analyses evaluated associations of medical nutrition therapy and inflammatory biomarkers (procalcitonin and C-reactive protein) with the outcome. Cox proportional hazards regression models were used, and five sequential models adjusted for confounders.
resultsOverall, 551 patients (36.3%) developed oral mucosal membrane pressure injuries. Nutrition risk was independently associated with an increased risk (hazard ratio [HR] = 1.37; 95% CI, 1.07-1.75). Medical nutrition therapy, including enteral nutrition, parenteral nutrition, and combined therapy, was associated with a reduced risk compared with suspended diet, with longer durations conferring greater benefit (HR = 0.77; 95% CI, 0.74-0.80). Additionally, elevated procalcitonin levels were associated with an increased risk of oral mucosal membrane pressure injuries (HR = 1.35; 95% CI, 1.09-1.68), whereas high C-reactive protein levels, although not statistically significant (HR = 1.09; 95% CI, 0.91-1.30), suggested a potential promoting effect.
conclusionNutrition risk was an independent risk factor for oral mucosal membrane pressure injuries in critically ill patients with endotracheal tubes. Medical nutrition therapy reduced this risk, particularly with longer durations. Additionally, elevated procalcitonin levels were associated with a higher risk, highlighting the role of inflammation in pressure injury development.
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