Evidence map›Paper›PMID 40798246›Full record

ArticleOptics express2025

Experimental comparison of X-ray ptychographic and holographic nanotomography of metal-stained neuronal tissue.

Alexandra Pacureanu, Thomas Thies, Carles Bosch, Mirko Holler, Manuel Guizar-Sicairos, Elisabeth Müller, Joakim Reuteler, Dmitry Karpov, Andreas T Schaefer, Peter Cloetens and 2 more

Abstract readComparative Study
In one paragraph

Article in Optics express, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Alexandra Pacureanu
Thomas Thies
Carles Bosch
Mirko Holler
Manuel Guizar-Sicairos
Elisabeth Müller
Joakim Reuteler
Dmitry Karpov
Andreas T Schaefer
Peter Cloetens
Andreas Menzel
Ana Diaz

Funding

Wellcome Trust CC2036
6 · The paper itself

Abstract

Hard X-ray nanotomography is a promising technology for nondestructive imaging of biological tissues with three-dimensional isotropic resolution. The implementation of fourth-generation synchrotron sources brings coherent X-ray microscopy to the central stage and fosters further development of this class of techniques. Here, we present an experimental comparison of X-ray near-field ptychography and X-ray holography, two high-resolution X-ray microscopy techniques applied under cryogenic conditions to the exact same sample at two different synchrotron sources. Using a heavy-metal-stained, resin-embedded brain tissue sample, we obtain similar contrast and spatial resolutions at equivalent radiation doses with these two approaches. We discuss the current benefits and limitations of the two methods. These results provide a basis for developments in X-ray microscopy of biological samples at present and future beamlines of fourth-generation synchrotron sources.

Indexed as

HolographyNanotechnologyNeuronsAnimalsBrainMicroscopyStaining and LabelingSynchrotronsX-Rays

Identifiers

PMID40798246
PMCPMC12329787

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.