Evidence map›Paper›PMID 40797314›Full record

ArticleBMC ophthalmology2025

Autoimmune encephalitis associated with antibodies against α-enolase sequestrated from degenerating retina in retinitis pigmentosa.

Qun Zeng, Jin Ming Lin, Androniki Syrrou, Onur İnam, Sarah Flanagan Wesley, Tongalp H Tezel

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Qun ZengDepartment of Ophthalmology, Vagelos College of Physicians and Surgeons, Edward S. Harkness Eye Institute, Columbia University Irving Medical Center, 622 West 168th Street, 18th Floor, Suite 18201B, Mailbox 200, New York, NY, 10032, USA.
Jin Ming LinCity University of New York School of Medicine, New York, NY, USA.
Androniki SyrrouDepartment of Ophthalmology, Vagelos College of Physicians and Surgeons, Edward S. Harkness Eye Institute, Columbia University Irving Medical Center, 622 West 168th Street, 18th Floor, Suite 18201B, Mailbox 200, New York, NY, 10032, USA.
Onur İnamDepartment of Ophthalmology, Vagelos College of Physicians and Surgeons, Edward S. Harkness Eye Institute, Columbia University Irving Medical Center, 622 West 168th Street, 18th Floor, Suite 18201B, Mailbox 200, New York, NY, 10032, USA.
Sarah Flanagan WesleyDepartment of Neurology, Neuroimmunology Division, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.
Tongalp H TezelDepartment of Ophthalmology, Vagelos College of Physicians and Surgeons, Edward S. Harkness Eye Institute, Columbia University Irving Medical Center, 622 West 168th Street, 18th Floor, Suite 18201B, Mailbox 200, New York, NY, 10032, USA. tht2115@cumc.columbia.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRetinitis pigmentosa is a group of inherited retinal degenerations resulting in photoreceptor cell dysfunction, death, and eventually vision loss. It can be a manifestation of Usher syndrome and has been linked with autoimmune retinopathy and systemic autoimmune diseases. CASE PRESENTATION: We report the case of a 70-year-old woman with retinitis pigmentosa and Usher syndrome who presented with autoimmune encephalitis. Laboratory tests revealed the presence of α-enolase antibodies in the patient's serum and cerebrospinal fluid, which cross-reacted with the human brain and retina tissues.

conclusionsWe describe autoimmune encephalitis caused by autoantibodies against sequestrated retinal antigens in retinitis pigmentosa, which can cross-react with brain tissue. This unique case demonstrates the remote effects of retinitis pigmentosa and an autoimmune pathogenetic pathway that triggered autoimmune encephalitis. Several retinal antigens sequestered into systemic circulation with outer retinal degeneration in retinitis pigmentosa can evoke an immune response and thus produce auto-antibodies that can result in autoimmune encephalitis.

Indexed as

AutoantibodiesEncephalitisHashimoto DiseasePhosphopyruvate HydrataseRetinaRetinitis PigmentosaAgedFemaleHumansAutoantibodiesPhosphopyruvate HydrataseAutoimmune encephalitisAutoimmune retinopathyRetinitis pigmentosaΑ-enolase antibodies

Identifiers

PMID40797314
PMCPMC12341249

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.