SynthesisBMC surgery2025
The effect of dexamethasone in laparoscopic abdominal surgery - a review on inflammatory markers for stress response.
Synthesis in BMC surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- The effect of dexamethasone on inflammatory markers of surgical stress: a randomized trial in robotic hysterectomy.BMC surgery · 2026Trial
- Gut-brain axis disruption, intestinal barrier damage, and systemic inflammation as predictors of POCD after cholecystectomy: a nested case-control study.Frontiers in medicine · 2026Article
- Salivary Cortisol as a Surrogate Marker of Stress Response in Children Undergoing Laparoscopic Surgery with Low-pressure versus Standard-pressure Pneumoperitoneum.Journal of Indian Association of Pediatric SurgeonsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe aimed to perform a review focused on the effects of dexamethasone on markers of surgical stress in the context of laparoscopic abdominal surgery.
methodsThis review was registered at PROSPERO. Published reports were evaluated with COVIDENCE, focusing on randomized controlled trials from the MEDLINE, EMBASE and CENTRAL databases. Studies were included if they compared a single intravenous dose of dexamethasone to placebo given preoperatively to adult patients undergoing laparoscopic or robotic assisted abdominal surgery under general anesthesia. The outcome of interest was inflammatory response in general and in particular c-reactive protein.
resultsOut of 588 references, we included seven studies. These involved a variety of surgical procedures, with cholecystectomies being the most common, and included mixed gender populations except in studies on gynecology surgery. Due to the heterogeneity in outcomes and the low number of studies no meta-analysis was performed. Levels of c-reactive protein was 38-60 % lower at 24 to 48 hours postoperatively with a dose of 8 mg dexamethasone compared to placebo, predominantly in cholecystectomy cases. Post-trial calculation indicates that the power of these studies ranged between 60% and 95%.
conclusionOur review may indicate a reduction of surgical stress in laparoscopic abdominal surgery measured by c-reactive protein, when a single dose of dexamethasone is administered.
trial registrationPROSPERO: CRD 42024421062.
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