Evidence map›Paper›PMID 40797070›Full record

ArticleScientific reports2025

2-aminoethoxydiphenylborane intervenes intracellular calcium signaling and attenuates myocardial ischemia-reperfusion injury in mice through ITPR1/MCU pathway.

Hailong Bao, Xin Chen, Xi Hu, Zhaoxing Cao, Wei Zhou, Bingxiu Chen, Fujun Liao, Fang Wei, Runze Huang, Wei Li and 1 more

Erratum issuedAbstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Hailong Bao *Department of Cardiovascular Medicine, The Affiliated Hospital of Guizhou Medical University, Guiyang, 550004, Guizhou, China.
Xin Chen *Department of Cardiovascular Medicine, The Affiliated Hospital of Guizhou Medical University, Guiyang, 550004, Guizhou, China.
Xi Hu *Department of Cardiovascular Medicine, The Affiliated Hospital of Guizhou Medical University, Guiyang, 550004, Guizhou, China.
Zhaoxing Cao *Department of Cardiovascular Medicine, The Affiliated Hospital of Guizhou Medical University, Guiyang, 550004, Guizhou, China.
Wei ZhouDepartment of Cardiovascular Medicine, The Affiliated Hospital of Guizhou Medical University, Guiyang, 550004, Guizhou, China.
Bingxiu ChenDepartment of Cardiovascular Medicine, The Affiliated Hospital of Guizhou Medical University, Guiyang, 550004, Guizhou, China.
Fujun LiaoDepartment of Cardiovascular Medicine, The Affiliated Hospital of Guizhou Medical University, Guiyang, 550004, Guizhou, China.
Fang WeiDepartment of Cardiovascular Medicine, The Affiliated Hospital of Guizhou Medical University, Guiyang, 550004, Guizhou, China.
Runze HuangDepartment of Cardiovascular Medicine, The Affiliated Hospital of Guizhou Medical University, Guiyang, 550004, Guizhou, China. runzehuang@pku.org.cn.
Wei LiDepartment of Cardiovascular Medicine, The Affiliated Hospital of Guizhou Medical University, Guiyang, 550004, Guizhou, China. liwei249188@sina.com.
Zhangrong ChenDepartment of Cardiovascular Medicine, The Affiliated Hospital of Guizhou Medical University, Guiyang, 550004, Guizhou, China. chenzhangrong71@163.com.

Funding

National Natural Science Foundation of China 32460222National Natural Science Foundation of China 81960047National Natural Science Foundation of China 81960085
6 · The paper itself

Abstract

Myocardial ischemia-reperfusion (MI/R) injury frequently occurs during the clinical management of ischemic heart disease. The underlying mechanism includes neutrophil infiltration, heightened intracellular Ca

Indexed as

Boron CompoundsCalcium ChannelsCalcium SignalingInositol 1,4,5-Trisphosphate ReceptorsMyocardial Reperfusion InjuryAnimalsCalciumCardiotonic AgentsDisease Models, AnimalMaleMiceMice, Inbred C57BLMitochondriaMitochondrial ProteinsMyocytes, Cardiac2-aminoethoxydiphenyl borateBoron CompoundsCalciumCalcium ChannelsCardiotonic AgentsInositol 1,4,5-Trisphosphate ReceptorsItpr1 protein, mouseMcu protein, mouseMitochondrial Proteins2-aminoethoxydiphenylboraneCalcium overloadInositol 1,4,5-trisphosphate receptorMitochondriaMitochondrial calcium uniporterMyocardial ischemia-reperfusion

Identifiers

PMID40797070
PMCPMC12343832

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.