Evidence map›Paper›PMID 40797064›Full record

ArticleScientific reports2025

Focused ultrasound suppresses pentylenetetrazol-induced epileptiform activity in rats and alters connectivity measured by functional MRI.

Po-Chun Chu, Wei-Hong Ruan, Chen-Syuan Huang, Yi-Jing Juan, Jyh-Horng Chen, Hsiang-Yu Yu, Robert S Fisher, Hao-Li Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Po-Chun ChuDepartment of Electrical Engineering, National Taiwan University, Taipei, Taiwan, ROC.
Wei-Hong RuanGraduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan, ROC.
Chen-Syuan HuangDepartment of Electrical Engineering, National Taiwan University, Taipei, Taiwan, ROC.
Yi-Jing JuanGraduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan, ROC.
Jyh-Horng ChenDepartment of Electrical Engineering, National Taiwan University, Taipei, Taiwan, ROC.
Hsiang-Yu YuDepartment of Neurology, Taipei Veteran General Hospital, Taipei, Taiwan.
Robert S FisherDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Palo Alto, CA, USA.
Hao-Li LiuDepartment of Electrical Engineering, National Taiwan University, Taipei, Taiwan, ROC. hlliu@ntu.edu.tw.

Funding

National Science and Technology Council 111-2221-E-002 -032 -MY3
6 · The paper itself

Abstract

Focused ultrasound (FUS) has emerged as a promising neuromodulation technique for reducing regional brain excitability, offering a potential therapeutic approach for drug-resistant epilepsy (DRE). However, its underlying mechanisms remain unclear, particularly regarding functional connectivity alterations in seizure-related brain networks. This study investigates the relationship between FUS-induced seizure suppression and brain functional connectivity using EEG and resting-state fMRI (rs-fMRI). Using a pentylenetetrazol (PTZ)-induced epilepsy rat model (n = 28), we applied burst-mode FUS with 0.25 MI, I

Indexed as

EpilepsyMagnetic Resonance ImagingPentylenetetrazoleAnimalsBrainDisease Models, AnimalElectroencephalographyHippocampusMaleNerve NetRatsRats, Sprague-DawleySeizuresPentylenetetrazoleFocused ultrasoundGeneralized epilepsyNeuromodulationPTZ model

Identifiers

PMID40797064
PMCPMC12343953

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.